Purpose of Review

Opioid use disorder (OUD) remains a national epidemic with an immense consequence to the United States’ healthcare system. Current therapeutic options are limited by adverse effects and limited efficacy.

Recent Findings

Recent advances in therapeutic options for OUD have shown promise in the fight against this ongoing health crisis. Modifications to approved medication-assisted treatment (MAT) include office-based methadone maintenance, implantable and monthly injectable buprenorphine, and an extended-release injectable naltrexone. Therapies under investigation include various strategies such as heroin vaccines, gene-targeted therapy, and biased agonism at the G protein-coupled receptor (GPCR), but several pharmacologic, clinical, and practical barriers limit these treatments’ market viability.

Summary

This manuscript provides a comprehensive review of the current literature regarding recent innovations in OUD treatment.

中文翻译：

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阿片类药物使用障碍治疗的最新进展

审查目的

阿片类药物使用障碍 (OUD) 仍然是一种全国性流行病，对美国的医疗保健系统造成巨大影响。当前的治疗选择受到副作用和有限功效的限制。

最近的发现

OUD 治疗方案的最新进展已显示出对抗这一持续健康危机的希望。对批准的药物辅助治疗 (MAT) 的修改包括基于办公室的美沙酮维持、可植入和每月注射丁丙诺啡，以及缓释注射纳曲酮。正在研究的疗法包括各种策略，例如海洛因疫苗、基因靶向疗法和 G 蛋白偶联受体 (GPCR) 的偏向激动，但一些药理学、临床和实践障碍限制了这些疗法的市场可行性。

概括

这份手稿全面回顾了当前有关 OUD 治疗最新创新的文献。