Previous studies demonstrated the possible involvement of insula in suicide owing to depression. However, the function of insula in young depressed patients with suicide attempt (SA) remains to be revealed. This study aimed to explore the association between resting-state functional connectivity (FC) of insula and SA in young depressed patients. Fifty-eight adolescents and young adults with major depressive disorder, including 22 with a history of at least one SA (SA group) and 36 without a history of SA (NSA group) were scanned with a 3.0T functional magnetic resonance imaging system, and the resting-state functional magnetic resonance imaging data was extracted. Whole brain resting-state FC of insular subdivisions were compared between the two groups. Significantly increased FC of the left posterior insula with the orbital part of left inferior frontal gyrus, the right supplementary motor area and the bilateral paracentral lobule extending to the bilateral middle cingulate cortex was observed in the SA group compared with the NSA group. In addition, the orbital part of left superior frontal gyrus in the SA group exhibited significantly increased FC with the right posterior insula compared with the NSA group. However, no significant correlation was found between the insular subdivisions FC and different clinical variables in two groups. The present study highlighted the disruptions of the resting-state FC of the posterior insula with the orbitofrontal cortex and a series of motor cortices, and added incremental value to the knowledge of the neural mechanism underlying SA in young depressed patients.

先前的研究表明，绝缘可能会因抑郁而参与自杀。然而，在年轻的自杀未遂（SA）抑郁症患者中的岛突功能仍有待揭示。这项研究旨在探讨年轻抑郁症患者的岛状静息状态功能连接（FC）和SA之间的关联。用3.0T功能磁共振成像系统扫描了58例重度抑郁症的青少年，包括22例至少有SA病史的患者（SA组）和36例没有SA病史的患者（NSA组），并使用3.0T功能磁共振成像系统进行了扫描，提取静止状态功能磁共振成像数据。在两组之间比较了岛状细分的全脑静息状态FC。与NSA组相比，SA组观察到左后岛的FC显着增加，左下额回的眼眶部分，右辅助运动区和双侧中央小叶延伸至双侧扣带回皮层。此外，与NSA组相比，SA组左上额回的眼眶部分显示FC显着增加。但是，在岛内FC和两组不同的临床变量之间未发现显着相关性。本研究强调了眶额叶皮层和一系列运动皮层对后岛小岛静息状态FC的破坏，