Abstract—

Bacilli control behavioral reactions such as motility, biofilm formation, production of enzymes and metabolites, differentiation, and others by integrating a variety of environmental signals through a complex regulatory network. In the natural environment, Bacillus subtilis exists predominantly in the form of biofilms, which has made it an ideal model for studying the molecular strategy of biofilm formation. This paper systematizes information on the main regulatory systems responsible for the loss of mobility and the formation of B. subtilis biofilms, analyzes the behavior of bacteria within the biofilm population, leading to a state of bistability and differentiation into different types of subpopulations. It also evaluates the regulatory relationship between control systems responsible for the synthesis of structural components in the biofilm matrix. Particular emphasis is placed on data concerning signaling mechanisms that trigger the formation of a biofilm and its dispersion. In general, we summarize information about the latest discoveries in this area and their integration into the general idea of these complex microbial communities.

中文翻译：

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枯草芽孢杆菌固定期的双稳态和生物膜基质的形成作为适应性机制。

摘要—

芽孢杆菌通过复杂的调节网络整合各种环境信号来控制行为反应，例如运动性，生物膜形成，酶和代谢产物的产生，分化等。在自然环境中，枯草芽孢杆菌主要以生物膜的形式存在，这使其成为研究生物膜形成的分子策略的理想模型。本文将导致流失性丧失和枯草芽孢杆菌形成的主要监管体系的信息系统化生物膜，分析生物膜种群中细菌的行为，从而导致双稳态并分化为不同类型的亚群。它还评估了负责生物膜基质中结构成分合成的控制系统之间的调节关系。特别强调有关触发生物膜形成及其分散的信号传导机制的数据。总的来说，我们总结了有关该领域最新发现的信息，以及将它们整合到这些复杂微生物群落的总体思路中的信息。