ABSTRACT

In this study, doped strontium fluorapatite (Sr-FAP) nanopowders were synthesised by sol-gel and used as a coating to modify Ti-6Al-4V substrates through CO₂ laser cladding. The Ca ions of FAP were substituted by a different amount of Sr ions to increase bone cell differentiation and antibacterial properties. Lattice parameters and crystal size values of different samples decrease with increasing the amount of Sr ion. According to the morphological results, the laser cladding Sr doped FAP nanopowders can create homogenously and crack-free coating on the Ti-6Al-4V substrates. The 0.6SrFAP nanopowder sample had a more hydrophilic nature in comparison to other Sr doped FAP nanopowders. This sample showed antibacterial properties and high cell adhesion, spreading, and viability while provided a bioactive and favourable surface for bone tissue regeneration. Therefore, 0.6SrFAP nanopowder laser cladding on the surface of Ti-6Al-4VV implants seems to be promising for further in-vivo investigations in bone applications.

摘要

本研究采用溶胶-凝胶法合成掺杂的氟磷灰石锶（Sr-FAP）纳米粉体，并将其作为涂层通过CO _{2对Ti-6Al-4V基材进行改性。}激光熔覆。FAP 的 Ca 离子被不同量的 Sr 离子取代，以增加骨细胞分化和抗菌性能。不同样品的晶格参数和晶体尺寸值随着 Sr 离子量的增加而减小。根据形貌结果，激光熔覆 Sr 掺杂 FAP 纳米粉体可以在 Ti-6Al-4V 基底上形成均匀且无裂纹的涂层。与其他 Sr 掺杂的 FAP 纳米粉相比，0.6SrFAP 纳米粉样品具有更亲水的性质。该样品显示出抗菌特性和高细胞粘附、扩散和活力，同时为骨组织再生提供了生物活性和有利的表面。因此，Ti-6Al-4VV 植入物表面的 0.6SrFAP 纳米粉末激光熔覆似乎有望用于进一步的体内骨应用研究。