ABSTRACT

Background: This study aimed to compare the BMD status among the clinical subtypes of PD and healthy controls.

Methods: Sixty patients with PD and 30 healthy age- and sex-matched controls were included in this study. The patients were divided into postural instability gait difficulty-dominant type (PIGDDT) group and tremor-dominant type (TDT) group based on the Unified Parkinson’s Disease Rating Scale (UPDRS) score. BMD was measured using dual-energy X-ray absorptiometry scans in femoral and lumbar regions.

Results: The T-scores in femoral and lumbar regions were similar in all groups. The prevalence of osteopenia was higher than the prevalence of osteoporosis in all three groups for femoral regions. The prevalence of osteoporosis in the intertrochanteric region and total femur in the PIGDDT group was higher than in the TDT group and controls. Our data showed a trend toward higher prevalence of osteoporosis in the PIGDDT group.

Conclusion: The prevalence of osteopenia and osteoporosis may differ between clinical subtypes of PD and healthy controls. Osteopenia is more common than osteoporosis for all groups. The patients with PIGDDT of PD tended to have higher prevalence of osteoporosis, even at early stages of disease, compared to those with TDT and healthy controls.

摘要

背景：本研究旨在比较 PD 临床亚型和健康对照之间的 BMD 状态。

方法：本研究包括 60 名 PD 患者和 30 名年龄和性别匹配的健康对照。根据帕金森病统一评定量表（UPDRS）评分将患者分为姿势不稳步态困难主导型（PIGDDT）组和震颤主导型（TDT）组。BMD 是在股骨和腰部区域使用双能 X 射线吸收仪扫描测量的。

结果：所有组的股骨和腰椎区域的 T 值相似。在所有三组股骨区域中，骨质减少的患病率均高于骨质疏松症的患病率。PIGDDT 组股骨转子间区和全股骨骨质疏松症的患病率高于 TDT 组和对照组。我们的数据显示 PIGDDT 组骨质疏松症的患病率有更高的趋势。

结论： PD 的临床亚型和健康对照之间的骨质减少和骨质疏松症的患病率可能不同。对于所有群体，骨质减少症比骨质疏松症更常见。与 TDT 患者和健康对照者相比，PD PIGDDT 患者往往具有更高的骨质疏松症患病率，即使在疾病的早期阶段也是如此。