Abstract SARS-CoV-2 virus was first identified in the beginning of 2020 and has spread all over the world, causing the Coronavirus Disease 2019 (COVID-19) pandemic. The virus is a member of the Coronavirus family, which includes viruses that cause common cold, Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS). MERS and SARS are known by causing adverse events in pregnancy. Considering that SARS-CoV-2 is a new infection agent, little is known about the risk of its infection to human embryo/fetal development. However, SARS and MERS were associated with negative outcomes, such as miscarriage, preterm birth, intrauterine growth restriction and perinatal death. Here, we raise concerns and possibilities related the harmful potential of SARS-CoV-2 and COVID-19 to pregnancy, discussing symptoms, immunological changes during pregnancy, SARS-CoV-2 mutation rate (and the risks related to it). Finally, we point out recommendations to be performed by the scientific community and health care workers in order to identify and to manage potential risks to pregnant women and their babies.

中文翻译：

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怀孕期间的 COVID-19 和不良后果：巴西畸胎学信息服务中心的担忧和建议

摘要 SARS-CoV-2 病毒于 2020 年初首次被发现，并已在世界各地传播，导致 2019 年冠状病毒病（COVID-19）大流行。该病毒是冠状病毒家族的一员，该家族包括引起普通感冒、中东呼吸综合症（MERS）和严重急性呼吸综合症（SARS）的病毒。众所周知，MERS 和 SARS 会导致妊娠期不良事件。考虑到 SARS-CoV-2 是一种新的感染因子，人们对其感染对人类胚胎/胎儿发育的风险知之甚少。然而，SARS 和 MERS 与流产、早产、宫内生长受限和围产期死亡等负面结果相关。在这里，我们提出了与 SARS-CoV-2 和 COVID-19 对妊娠有害的潜在可能性的担忧和可能性，讨论了症状、妊娠期间的免疫变化、SARS-CoV-2 突变率（以及与之相关的风险）。最后，我们提出了科学界和卫生保健工作者应采取的建议，以识别和管理孕妇及其婴儿的潜在风险。