In a sample of individuals with ovarian cancer, we aimed to (a) identify factors associated with the psychosocial impact of genetic counseling and multigene panel testing, (b) identify factors associated with cancer genetics knowledge, and (c) summarize patient-reported recommendations to improve the genetic counseling and multigene panel testing process. Eligible participants in this secondary analysis of quantitative and qualitative survey data were English-speaking adults with ovarian cancer. Psychosocial impact was assessed using the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire. Knowledge of cancer genetics was assessed using the KnowGene scale. Significant predictors of MICRA and KnowGene scores were identified using multiple regression. Open-ended survey item responses were analyzed using conventional content analysis. Eighty-seven participants met eligibility criteria. A positive genetic test result was associated with greater adverse psychosocial impact (B = 1.13, p = 0.002). Older age (B = − 0.07, p = 0.044) and being a member of a minority racial or ethnic group (B = − 3.075, p = 0.033) were associated with lower knowledge, while a personal history of at least one other type of cancer (B = 1.975, p = 0.015) was associated with higher knowledge. In open-ended item responses, participants wanted clinicians to assist with family communication, improve result disclosure, and enhance patient and family understanding of results. A subset of individuals with ovarian cancer who receive a positive genetic test result may be at risk for adverse psychosocial outcomes. Tailored cancer genetics education is necessary to promote the equitable uptake of targeted ovarian cancer treatment and risk-reducing therapies. Interventions to enhance patient-clinician communication in this setting are a research priority.

在卵巢癌患者样本中，我们旨在 (a) 确定与遗传咨询和多基因小组测试的心理社会影响相关的因素，(b) 确定与癌症遗传学知识相关的因素，以及 (c) 总结患者报告的建议改进遗传咨询和多基因面板检测过程。对定量和定性调查数据进行二次分析的合格参与者是说英语的卵巢癌成人。使用癌症风险评估（MICRA）问卷的多维影响评估社会心理影响。使用 KnowGene 量表评估癌症遗传学知识。使用多元回归确定了 MICRA 和 KnowGene 评分的重要预测因子。开放式调查项目的回答使用传统的内容分析进行分析。八十七名参与者符合资格标准。阳性基因检测结果与更大的不良心理社会影响有关（B  = 1.13，p  = 0.002）。年龄较大 ( B  = - 0.07, p  = 0.044) 和属于少数种族或族裔群体 ( B  = - 3.075, p  = 0.033) 与知识水平较低有关，而至少有其他类型的个人历史癌症 ( B  = 1.975, p = 0.015）与更高的知识相关。在开放式项目响应中，参与者希望临床医生协助家庭沟通，改进结果披露，并增强患者和家人对结果的理解。接受阳性基因检测结果的卵巢癌患者的子集可能面临不良心理社会后果的风险。量身定制的癌症遗传学教育对于促进公平接受靶向卵巢癌治疗和降低风险的治疗是必要的。在这种情况下加强医患沟通的干预措施是研究重点。