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Chronic pontine strokes: Diffusion tensor imaging of corticospinal tract indicates the prognosis in terms of motor outcome
Journal of X-Ray Science and Technology ( IF 1.7 ) Pub Date : 2021-03-06 , DOI: 10.3233/xst-200817
Qian Xue 1 , Xiao-Han Yang 1 , Gao-Jun Teng 2 , Shu-Dong Hu 1
Affiliation  

OBJECTIVE:To investigate relationship between the diffusion indexes of corticospinal tract (CST) and the neurological motor outcomes in chronic pontine stroke patients. METHODS:Diffusion tensor imaging (DTI) is performed in 27 patients with chronic pontine stroke. Fractional anisotropy (FA) valuesalong the CST area, the track number, and the CST length are measured. Neurological and motor outcomes are evaluated based on Fugl-meyer (FM), National Institutes of Health Stroke Scale (NIHSS), Barthel index (BI), and modified Rankin scale (mRS) scores. The relationships between FA ratios (rFAs) in the CST of stroke subjects and their clinical motor scores are analyzed through Spearman’s correlation analysis. Then, diffusion tensor tractography (DTT) is performed to show the injury degree of CST. RESULTS:First, FA values are decreased in the infarct area, cerebral peduncle, posterior limb of the internal capsule, and precentral gyrus compared with those in the contralateral side. The number of CST is decreased in the ipsilateral side of the infarct. Second, rFAs in the cerebral peduncle, posterior limb of the internal capsule, and CST rnum correlate positively with FM scores (r = 0.824, 0.672, 0.651, p < 0.001) and negatively with mRS scores (r = –0.835, –0.604, –0.645, p≤0.001). Third, the injury degree of CST correlates negatively with FM scores (r = –0.627, p < 0.001). CONCLUSIONS:The study demonstrates that rFAs in the cerebral peduncle, posterior limb of the internal capsule, and CST rnum associate with motor outcome, suggesting that DTI may be applicable for outcome evaluation.

中文翻译:

慢性脑桥卒中:皮质脊髓束的弥散张量成像表明运动结果方面的预后

目的:探讨慢性脑桥脑卒中患者皮质脊髓束扩散指数(CST)与神经运动功能结局的关系。方法:对 27 例慢性脑桥脑卒中患者进行弥散张量成像 (DTI)。测量沿 CST 区域、轨道编号和 CST 长度的分数各向异性 (FA) 值。根据 Fugl-meyer (FM)、美国国立卫生研究院卒中量表 (NIHSS)、Barthel 指数 (BI) 和改良 Rankin 量表 (mRS) 评分评估神经和运动结果。通过 Spearman 相关分析分析了卒中受试者 CST 中 FA 比 (rFA) 与其临床运动评分之间的关​​系。然后,进行扩散张量纤维束成像(DTT)以显示 CST 的损伤程度。结果:首先,梗死区FA值降低,脑脚、内囊后肢、中央前回与对侧比较。梗塞同侧的 CST 数量减少。其次,脑脚、内囊后肢和 CST rnum 中的 rFA 与 FM 评分呈正相关(r = 0.824、0.672、0.651,p < 0.001),与 mRS 评分呈负相关(r = –0.835、–0.604, –0.645,p≤0.001)。第三,CST 的损伤程度与 FM 评分呈负相关(r = –0.627,p < 0.001)。结论:该研究表明,脑脚、内囊后肢和 CST rnum 中的 rFAs 与运动结果相关,表明 DTI 可能适用于结果评估。和中央前回与对侧的相比。梗塞同侧的 CST 数量减少。其次,脑脚、内囊后肢和 CST rnum 中的 rFA 与 FM 评分呈正相关(r = 0.824、0.672、0.651,p < 0.001),与 mRS 评分呈负相关(r = –0.835、–0.604, –0.645,p≤0.001)。第三,CST 的损伤程度与 FM 评分呈负相关(r = –0.627,p < 0.001)。结论:该研究表明,脑脚、内囊后肢和 CST rnum 中的 rFAs 与运动结果相关,表明 DTI 可能适用于结果评估。和中央前回与对侧的相比。梗塞同侧的 CST 数量减少。其次,脑脚、内囊后肢和 CST rnum 中的 rFA 与 FM 评分呈正相关(r = 0.824、0.672、0.651,p < 0.001),与 mRS 评分呈负相关(r = –0.835、–0.604, –0.645,p≤0.001)。第三,CST 的损伤程度与 FM 评分呈负相关(r = –0.627,p < 0.001)。结论:该研究表明,脑脚、内囊后肢和 CST rnum 中的 rFAs 与运动结果相关,表明 DTI 可能适用于结果评估。和 CST rnum 与 FM 分数呈正相关(r = 0.824、0.672、0.651,p < 0.001),与 mRS 分数呈负相关(r = –0.835、–0.604、–0.645、p≤0.001)。第三,CST 的损伤程度与 FM 评分呈负相关(r = –0.627,p < 0.001)。结论:该研究表明,脑脚、内囊后肢和 CST rnum 中的 rFAs 与运动结果相关,表明 DTI 可能适用于结果评估。和 CST rnum 与 FM 分数呈正相关(r = 0.824、0.672、0.651,p < 0.001),与 mRS 分数呈负相关(r = –0.835、–0.604、–0.645、p≤0.001)。第三,CST 的损伤程度与 FM 评分呈负相关(r = –0.627,p < 0.001)。结论:该研究表明,脑脚、内囊后肢和 CST rnum 中的 rFAs 与运动结果相关,表明 DTI 可能适用于结果评估。
更新日期:2021-03-09
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