A selected set of new N1-(indan-5-yl)amidrazones 4a-p, encompassing piperazines or related amines, has been prepared via interaction of the hydrazonoyl chloride 3 (derived from 5-aminoindane) with the appropriate sec-cyclic amine in the presence of triethylamine. Their suggested structures are supported by IR, ¹H NMR, ¹³C NMR, high-resolution MS (ESI) spectral data, and further confirmed by single-crystal X-ray crystallography for 4k. These novel compounds were screened for their antitumor activity against breast cancer cells (MCF7 and T47D); amongst all of them, only compound 4o, incorporating N-(pyrimidin-2-yl)piperazine, was fairly active with IC₅₀ values of 69 μM and 61 μM, respectively.

通过将hydr酰氯3（衍生自5-氨基茚满）与适当的仲环胺相互作用，制得了一组选定的新N1-（茚满-5-基）氨基dra 4a-p，包括哌嗪或相关胺。三乙胺的存在。IR，¹ H NMR，¹³ C NMR，高分辨率MS（ESI）光谱数据支持了它们的建议结构，并通过单晶X射线晶体学对4k进行了进一步证实。筛选了这些新型化合物对乳腺癌细胞（MCF7和T47D）的抗肿瘤活性。在所有这些化合物中，只有掺有N-（嘧啶-2-基）哌嗪的化合物4o具有相当高的活性，IC ₅₀值分别为69μM和61μM。