Biofabrication of Gold Nanotriangles Using Liposomes as a Dual Functional Reductant and Stabilizer,Langmuir

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Biofabrication of Gold Nanotriangles Using Liposomes as a Dual Functional Reductant and Stabilizer
Langmuir ( IF 3.7 ) Pub Date : 2021-03-08 , DOI: 10.1021/acs.langmuir.1c00104
Jackeline Soto-Cruz _{1,

2} , Paolo Conejo-Valverde ₁ , Giovanni Sáenz-Arce ₃ , Hongjing Dou ₂ , Oscar Rojas-Carrillo _{1,

4}

Affiliation

Negatively charged liposomes accomplished both functions as a reducing and stabilizing agent in the synthesis of gold nanotriangles (GNTs). Liposomes are based on a mixture of phospholipids phosphatidylcholine/phosphoglycerol, and they were used as a template phase to perform the GNTs. The method was evaluated under different conditions such as temperature, reaction time, phosphoglycerol chain length, and precursor concentration. Isotropic and anisotropic gold nanoparticles are formed simultaneously during the synthesis. Therefore, by combining centrifugation and depletion flocculation strategies, the sample was concentrated in terms of GNTs from 15% crude to 80% by using sodium dodecyl sulfate (SDS). As a result, a green colored dispersion was obtained containing highly purified, well-defined, negatively charged GNTs, where the edge length of most particles is centered in the range of 60–80 nm with an average thickness of 7.8 ± 0.1 nm. By this purification process, it was possible to highly increase the yield in terms of GNTs. Other surfactants [cetyltrimethylammonium chloride (CTAC), hexadecyltrimethylammonium bromide (CTAB), Tween 20, and dodecyldimethylammonium bromide] were evaluated during the purification stage, and both CTAB and CTAC show similar results to those obtained by using SDS. These GNTs are potential candidates for future applications in molecular imaging, photothermal therapy, drug delivery, biosensing, and photodynamic therapy.

中文翻译：

金纳米三角形的生物制备使用脂质体作为双重功能的还原剂和稳定剂。

带负电的脂质体在金纳米三角形（GNT）的合成中既起到还原剂的作用，又起到稳定剂的作用。脂质体基于磷脂磷脂酰胆碱/磷酸甘油的混合物，它们被用作模板相来进行GNT。该方法在不同条件下进行了评估，例如温度，反应时间，磷酸甘油链长和前体浓度。在合成过程中同时形成各向同性和各向异性的金纳米粒子。因此，通过结合离心和耗竭絮凝策略，使用十二烷基硫酸钠（SDS）将样品的GNT含量从15％粗品浓缩到80％。结果，获得了绿色分散体，其中包含高度纯化的，定义明确的，带负电荷的GNT，其中大多数粒子的边缘长度位于60–80 nm的范围内，平均厚度为7.8±0.1 nm。通过该纯化方法，可以大大提高就GNT而言的产率。在纯化阶段还评估了其他表面活性剂[十六烷基三甲基氯化铵（CTAC），十六烷基三甲基溴化铵（CTAB），吐温20和十二烷基二甲基溴化铵]，CTAB和CTAC均显示出与使用SDS得到的结果相似的结果。这些GNT是分子成像，光热疗法，药物递送，生物传感和光动力疗法中未来应用的潜在候选者。在纯化阶段还评估了其他表面活性剂[十六烷基三甲基氯化铵（CTAC），十六烷基三甲基溴化铵（CTAB），吐温20和十二烷基二甲基溴化铵]，CTAB和CTAC均显示出与使用SDS得到的结果相似的结果。这些GNT是分子成像，光热疗法，药物递送，生物传感和光动力疗法中未来应用的潜在候选者。在纯化阶段还评估了其他表面活性剂[十六烷基三甲基氯化铵（CTAC），十六烷基三甲基溴化铵（CTAB），吐温20和十二烷基二甲基溴化铵]，CTAB和CTAC均显示出与使用SDS得到的结果相似的结果。这些GNT是分子成像，光热疗法，药物递送，生物传感和光动力疗法中未来应用的潜在候选者。

更新日期：2021-03-23

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