The lipolysis-stimulated lipoprotein receptor (LSR) displays an important regulatory role in cancer. However, the association between LSR and lung cancer is still elusive. Here, the candidate oncogene LSR on Ch.9q was obtained and assessed by bioinformatics analysis of The Cancer Genome Atlas (TCGA) dataset of lung cancer. We conducted clinical pathology and survival analysis based on the lung cancer database. We assessed the biological effects of LSR in lung cancer cells on cell proliferation. Our data indicated that LSR was upregulated in lung cancer cells. Meanwhile, LSR was identified in this study to be a poor prognostic factor, and its high expression exhibited relations with grades, stages, and nodal metastasis status. Using in vitro analysis, our data revealed that LSR could promote lung cancer progression by regulating cell proliferation, migration, and invasion. In our study, our data demonstrated that LSR was a tumor promoter for lung cancer and was a potential biomarker and target for lung cancer prognosis and treatment.

中文翻译：

---

LSR 促进肺癌细胞增殖和侵袭

脂解刺激脂蛋白受体 (LSR) 在癌症中显示出重要的调节作用。然而，LSR与肺癌之间的关联仍然难以捉摸。在这里，Ch.9q 上的候选癌基因 LSR 是通过肺癌癌症基因组图谱 (TCGA) 数据集的生物信息学分析获得和评估的。我们基于肺癌数据库进行了临床病理学和生存分析。我们评估了 LSR 在肺癌细胞中对细胞增殖的生物学影响。我们的数据表明 LSR 在肺癌细胞中上调。同时，本研究发现 LSR 是一个不良预后因素，其高表达与分级、分期和淋巴结转移状态有关。体外使用分析，我们的数据显示 LSR 可以通过调节细胞增殖、迁移和侵袭来促进肺癌进展。在我们的研究中，我们的数据表明 LSR 是肺癌的肿瘤促进剂，是肺癌预后和治疗的潜在生物标志物和靶标。