The pathogenesis of cancer is influenced by interactions among genes, proteins, metabolites and other small molecules. Understanding cancer progression at the metabolic level is propitious to the visual decoding of changes in living organisms. To date, a large number of metabolic biomarkers in cancer have been measured and reported, which provide an alternative method for cancer precision diagnosis, treatment and prognosis. To systematically understand the heterogeneity of cancers, we developed the database CMBD to integrate the cancer metabolic biomarkers scattered over literatures in PubMed. At present, CMBD contains 438 manually curated relationships between 282 biomarkers and 76 cancer subtypes of 18 tissues reported in 248 literatures. Users can access the comprehensive metabolic biomarker information about cancers, references, clinical samples and their relationships from our online database. As case studies, pathway analysis was performed on the metabolic biomarkers of breast and prostate cancers, respectively. ‘Phenylalanine, tyrosine and tryptophan biosynthesis’, ‘phenylalanine metabolism’ and ‘primary bile acid biosynthesis’ were identified as playing key roles in breast cancer. ‘Glyoxylate and dicarboxylate metabolism’, ‘citrate cycle (TCA cycle)’, and ‘alanine, aspartate and glutamate metabolism’ have important functions in prostate cancer. These findings provide us with an understanding of the metabolic pathway of cancer initiation and progression.

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CMBD：手动策划的癌症代谢生物标志物知识数据库

癌症的发病机制受基因、蛋白质、代谢物和其他小分子之间相互作用的影响。了解代谢水平的癌症进展有利于对生物体变化的视觉解码。迄今为止，已经测量并报道了大量癌症中的代谢生物标志物，为癌症精准诊断、治疗和预后提供了一种替代方法。为了系统地了解癌症的异质性，我们开发了数据库 CMBD 来整合分散在 PubMed 文献中的癌症代谢生物标志物。目前，CMBD 包含 248 篇文献报道的 18 种组织的 282 种生物标志物和 76 种癌症亚型之间的 438 种人工管理的关系。用户可以访问关于癌症、参考文献、来自我们在线数据库的临床样本及其关系。作为案例研究，分别对乳腺癌和前列腺癌的代谢生物标志物进行了通路分析。“苯丙氨酸、酪氨酸和色氨酸生物合成”、“苯丙氨酸代谢”和“初级胆汁酸生物合成”被确定为在乳腺癌中起关键作用。“乙醛酸和二羧酸代谢”、“柠檬酸循环（TCA 循环）”和“丙氨酸、天冬氨酸和谷氨酸代谢”在前列腺癌中具有重要作用。这些发现让我们了解了癌症发生和发展的代谢途径。酪氨酸和色氨酸生物合成”、“苯丙氨酸代谢”和“初级胆汁酸生物合成”被确定为在乳腺癌中起关键作用。“乙醛酸和二羧酸代谢”、“柠檬酸循环（TCA 循环）”和“丙氨酸、天冬氨酸和谷氨酸代谢”在前列腺癌中具有重要作用。这些发现让我们了解了癌症发生和发展的代谢途径。酪氨酸和色氨酸生物合成”、“苯丙氨酸代谢”和“初级胆汁酸生物合成”被确定为在乳腺癌中起关键作用。“乙醛酸和二羧酸代谢”、“柠檬酸循环（TCA 循环）”和“丙氨酸、天冬氨酸和谷氨酸代谢”在前列腺癌中具有重要作用。这些发现让我们了解了癌症发生和发展的代谢途径。