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Effects of radiofrequency electromagnetic radiation emitted from a mobile phone base station on the redox homeostasis in different organs of Swiss albino mice
Electromagnetic Biology and Medicine ( IF 1.6 ) Pub Date : 2021-03-09 , DOI: 10.1080/15368378.2021.1895207
Mary Zosangzuali 1 , Marina Lalremruati 1 , C Lalmuansangi 1 , F Nghakliana 1 , Lalrinthara Pachuau 2 , Priyanka Bandara 3 , Zothan Siama 1
Affiliation  

ABSTRACT

This study was designed to investigate the possible effects of exposure to mobile phone base station (MPBS) emits 1800-MHz RF-EMR on some oxidative stress parameters in the brain, heart, kidney and liver of Swiss albino mice under exposures below thermal levels. Mice were randomly assigned to three experimental groups which were exposed to RF-EMR for 6 hr/day, 12 hr/day and 24 hr/day for 45 consecutive days, respectively, and a control group. The glutathione (GSH) levels and activities of glutathione-s-transferase (GST) and superoxide dismutase (SOD) were significantly reduced in mice brain after exposure to RF-EMR for 12 hr and 24 hr per day. Exposure of mice to RF-EMR for 12 hr and 24 hr per day also led to a significant increase in malondialdehyde (an index of lipid peroxidation) levels in mice brain. On the contrary, exposures used in this study did not induce any significant change in various oxidative stress-related parameters in the heart, kidney and liver of mice. Our findings showed no significant variations in the activities of aspartate amino-transferase (AST), alanine amino-transferase (ALT), and on the level of creatinine (CRE) in the exposed mice. This study also revealed a decrease in RBC count with an increase in WBC count in mice subjected to 12 hr/day and 24 hr/day exposures. Exposure to RF-EMR from MPBS may cause adverse effects in mice brain by inducing oxidative stress arising from the generation of reactive oxygen species (ROS) as indicated by enhanced lipid peroxidation, and reduced levels and activities of antioxidants.



中文翻译:

手机基站射频电磁辐射对瑞士白化小鼠不同器官氧化还原稳态的影响

摘要

本研究旨在调查暴露于手机基站 (MPBS) 发出的 1800-MHz RF-EMR 对暴露于低于热水平的瑞士白化小鼠的大脑、心脏、肾脏和肝脏中的一些氧化应激参数的可能影响。小鼠被随机分配到三个实验组,分别暴露于 RF-EMR 6 小时/天、12 小时/天和 24 小时/天,连续 45 天,以及一个对照组。每天暴露于 RF-EMR 12 小时和 24 小时后,小鼠大脑中谷胱甘肽 (GSH) 水平和谷胱甘肽-S-转移酶 (GST) 和超氧化物歧化酶 (SOD) 的活性显着降低。小鼠每天暴露于 RF-EMR 12 小时和 24 小时也导致小鼠大脑中丙二醛(脂质过氧化指数)水平的显着增加。相反,本研究中使用的暴露不会引起小鼠心脏、肾脏和肝脏中各种氧化应激相关参数的任何显着变化。我们的研究结果表明,暴露小鼠的天冬氨酸氨基转移酶 (AST)、丙氨酸氨基转移酶 (ALT) 和肌酐 (CRE) 水平没有显着变化。该研究还显示,在暴露于 12 小时/天和 24 小时/天的小鼠中,随着 WBC 计数的增加,RBC 计数减少。暴露于来自 MPBS 的 RF-EMR 可能会通过诱导由活性氧 (ROS) 产生引起的氧化应激对小鼠大脑造成不利影响,如脂质过氧化增强以及抗氧化剂水平和活性降低所示。小鼠的肾脏和肝脏。我们的研究结果表明,暴露小鼠的天冬氨酸氨基转移酶 (AST)、丙氨酸氨基转移酶 (ALT) 和肌酐 (CRE) 水平没有显着变化。该研究还显示,在暴露于 12 小时/天和 24 小时/天的小鼠中,随着 WBC 计数的增加,RBC 计数减少。暴露于 MPBS 的 RF-EMR 可能会通过诱导由活性氧 (ROS) 产生引起的氧化应激对小鼠大脑造成不利影响,如脂质过氧化增强以及抗氧化剂水平和活性降低所示。小鼠的肾脏和肝脏。我们的研究结果表明,暴露小鼠的天冬氨酸氨基转移酶 (AST)、丙氨酸氨基转移酶 (ALT) 和肌酐 (CRE) 水平没有显着变化。该研究还显示,在暴露于 12 小时/天和 24 小时/天的小鼠中,随着 WBC 计数的增加,RBC 计数减少。暴露于来自 MPBS 的 RF-EMR 可能会通过诱导由活性氧 (ROS) 产生引起的氧化应激对小鼠大脑造成不利影响,如脂质过氧化增强以及抗氧化剂水平和活性降低所示。该研究还显示,在暴露于 12 小时/天和 24 小时/天的小鼠中,随着 WBC 计数的增加,RBC 计数减少。暴露于来自 MPBS 的 RF-EMR 可能会通过诱导由活性氧 (ROS) 产生引起的氧化应激对小鼠大脑造成不利影响,如脂质过氧化增强以及抗氧化剂水平和活性降低所示。该研究还显示,在暴露于 12 小时/天和 24 小时/天的小鼠中,随着 WBC 计数的增加,RBC 计数减少。暴露于来自 MPBS 的 RF-EMR 可能会通过诱导由活性氧 (ROS) 产生引起的氧化应激对小鼠大脑造成不利影响,如脂质过氧化增强以及抗氧化剂水平和活性降低所示。

更新日期:2021-03-09
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