For decades, the synaptic vesicle cluster has been thought of as a storage space for synaptic vesicles, whose obvious function is to provide vesicles for the depolarization-induced release of neurotransmitters; however, reports over the last few years indicate that the synaptic vesicle cluster probably plays a much broader and more fundamental role in synaptic biology. Various experiments suggest that the cluster is able to regulate protein distribution and mobility in the synapse; moreover, it probably regulates cytoskeleton architecture, mediates the selective removal of synaptic components from the bouton, and controls the responses of the presynapse to plasticity. Here we discuss these features of the vesicle cluster and conclude that it serves as a key organizer of synaptic composition and dynamics.

几十年来，突触囊泡簇一直被认为是突触囊泡的储存空间，其明显的功能是为去极化诱导的神经递质释放提供囊泡；然而，过去几年的报告表明，突触囊泡簇可能在突触生物学中发挥着更广泛和更基本的作用。各种实验表明，该簇能够调节突触中的蛋白质分布和移动性；此外，它可能调节细胞骨架结构，介导从 bouton 中选择性去除突触成分，并控制突触前对可塑性的反应。在这里，我们讨论了囊泡簇的这些特征，并得出结论，它是突触组成和动力学的关键组织者。