Biomolecules in the secretory pathway use membrane trafficking for reaching their final intracellular destination or for secretion outside the cell. This highly dynamic and multipartite process involves different organelles that communicate to one another while maintaining their identity, shape, and function. Recent studies unraveled new mechanisms of interorganelle communication that help organize the early secretory pathway. We highlight how the spatial proximity between endoplasmic reticulum (ER) exit sites and early Golgi elements provides novel means of ER–Golgi communication for ER export. We also review recent findings on how membrane contact sites between the ER and the trans-Golgi membranes can sustain anterograde traffic out of the Golgi complex.

分泌途径中的生物分子利用膜运输到达其最终的细胞内目的地或分泌到细胞外。这一高度动态和多方的过程涉及不同的细胞器，它们在保持身份、形状和功能的同时相互交流。最近的研究揭示了帮助组织早期分泌途径的细胞器间通讯的新机制。我们强调了内质网 (ER) 出口位点和早期高尔基体元素之间的空间接近性如何为 ER 输出提供 ER-高尔基体通信的新方法。我们还回顾了最近关于 ER 和跨高尔基体膜之间的膜接触位点如何维持高尔基体复合体的顺行交通的最新发现。