In this study, solvent-cast polymeric films containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast polymeric films were prepared from two polymers, pectin and Eudragit^® NE 30D, by drying the polymeric solution in a hot air oven at 70 ± 3 °C for 10 h. Glycerin was used as a plasticizer. Lidocaine and aspirin were prepared in ionic liquid form and loaded into the patches. The physicomechanical properties of the films were characterized by texture analysis, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction. A scanning electron microscope was used to photograph the surfaces of solvent-cast polymeric films. Eudragit^® NE 30D significantly decreased the toughness and rigidity of the films. The transdermal patches were in the amorphous state, and their thermal properties were not changed from blank polymeric films. The surfaces of transdermal patches were rougher than blank polymeric films and revealed the distribution of the drug. Eudragit^® NE 30D significantly decreased the trends of entrapment efficiency and in vitro release of lidocaine and aspirin drugs. The kinetic release observed in vitro fitted to Higuchi’s model rather than zero and first order models, indicating that a diffusion mechanism governed the release of the drug from the patch. Thus, the solvent-cast polymeric films from two polymers, pectin and Eudragit^® NE 30D, are suitable for transdermal patches loaded with ionic liquid lidocaine/aspirin.

在这项研究中，开发了用于离子透皮贴剂的包含离子液体利多卡因/阿司匹林的溶剂浇铸聚合物薄膜。溶剂流延聚合物薄膜从两种聚合物，果胶和Eudragit制备^® NE 30D，通过干燥在热风温度为70±3℃的烘箱中10小时聚合物溶液中。甘油用作增塑剂。以离子液体形式制备利多卡因和阿司匹林，并装入贴剂中。通过质构分析，差示扫描量热法，热重分析和X射线衍射来表征膜的物理力学性能。使用扫描电子显微镜拍摄溶剂浇铸的聚合物膜的表面。丙烯酸树脂^®NE 30D大大降低了薄膜的韧性和刚度。透皮贴剂处于无定形状态，并且其热性质与空白的聚合物膜相比没有变化。透皮贴剂的表面比空白的聚合物膜更粗糙，并显示出药物的分布。丙烯酸树脂^® NE 30D显著下跌的包封率的趋势和体外释放利多卡因和阿斯匹林类药物。体外观察到的动力学释放符合Higuchi模型，而不是零阶和一阶模型，表明扩散机制决定了药物从贴剂中的释放。因此，从两种聚合物，果胶和Eudragit溶剂流延聚合物膜^® NE 30D适用于装有离子液体利多卡因/阿司匹林的透皮贴剂。