Metformin is the largest drug produced globally in metric tons. It has been reported in many water treatment plants and water resources. The analysis of metformin at trace level is important before supplying water to the communities. The present article describes solid-phase micromembrane tip extraction and capillary electrophoretic methods for the analysis of metformin in water using multi-walled carbon nanotubes as a sorbent in the sample preparation method. The maximum extraction of metformin was achieved at 10.0 mg/L metformin, 25 shaking time, 0.5 g/L CNTs dose, 7.0 sorption pH, 30-min desorption time and 12 desorption pH. The migration time of metformin was 8.4 min with 2.0 × 10^–4, 1.35 × 10^–4 and 15,600 as electrophoretic mobility (cm²V⁻¹ s⁻¹), electroosmotic mobility (cm²V⁻¹ s⁻¹) and the number of theoretical plates. These solid-phase micromembrane tip extraction and capillary electrophoretic methods were highly applicable to monitor metformin in the wastewater. The reported methods are efficient, reproducible and useful for the estimation of metformin in water and may be exploited for the analysis of the metformin water resource.

二甲双胍是全球生产的最大公吨药物。在许多水处理厂和水资源中都有报道。在向社区供水之前，对痕量二甲双胍进行分析非常重要。本文介绍了在样品制备方法中使用多壁碳纳米管作为吸附剂的固相微膜尖端萃取和毛细管电泳方法，用于分析水中的二甲双胍。在10.0 mg / L二甲双胍，25振摇时间，0.5 g / L CNTs剂量，7.0吸附pH，30分钟脱附时间和12脱附pH下获得了二甲双胍的最大提取量。二甲双胍的迁移时间为8.4分钟，2.0×10 ^-4，1.35×10 ^-4和15600作为电泳迁移率（厘米² V ^-1 s ^-1），电渗迁移率（cm ² V ^-1  s ^-1）和理论塔板数。这些固相微膜尖端提取和毛细管电泳方法非常适用于监测废水中的二甲双胍。所报道的方法高效，可重复且对估计水中的二甲双胍有用，可用于分析二甲双胍的水资源。