Purpose

Metabolic syndrome is a condition with clustering of risk factors like insulin resistance, obesity, dyslipidemia, and hypertension. Leptin is a protein of obese gene produced by white adipose tissue. Leptin resistance is the insensitivity of leptin in hypothalamus despite high amounts in blood causing obesity and metabolic syndrome. The study focused on the influence of a 12-week physical activity promotion program on leptin resistance in people with metabolic syndrome

Methods

After approval from institutional ethics committee (IEC 343-2018), 18 participants (males N= 4, females N=14) of age group 45.0±7.6 years with metabolic syndrome according to (NCEP ATP-III) criteria were included in the study. The participants underwent a 12-week physical activity program consisting of 150 min of moderate to vigorous activity per week as per GPAQ domains—work, transport, and recreation. The outcomes were measured at baseline and after 12 weeks.

Results

Out of 18 participants, 10 participants who completed the study were analysed. Twelve-week physical activity showed significant changes in waist circumference (p=0.047), post prandial blood glucose (p=0.0396), triglycerides (p=0.0323), body mass index (p=0.0056), subcutaneous fat (p=0.0354), and basal metabolic rate (p=0.0035). Fasting blood glucose (p=0.254), lipid profiles (total cholesterol (p=0.062)), high-density lipoprotein (p=0.367), low-density lipoprotein (p=0.641), and leptin showed insignificant change (p=0.328). Global physical activity questionnaire showed significant change (p=0.0254) suggesting changes in physical activity behaviors.

Conclusion

From present study, it is concluded that a 12-week physical activity promotion program brought marginal changes in leptin levels and has potential to modify metabolic syndrome parameters and improve physical activity.

中文翻译：

---

一项为期12周的体育锻炼计划对代谢综合征中瘦素抵抗的影响：一项初步研究

目的

代谢综合征是一种危险因素，例如胰岛素抵抗，肥胖，血脂异常和高血压。瘦素是由白色脂肪组织产生的肥胖基因的蛋白质。瘦素抵抗是下丘脑中瘦素的不敏感性，尽管血液中大量导致肥胖和代谢综合征。该研究集中于一项为期12周的体育锻炼促进计划对代谢综合征患者瘦素抵抗的影响

方法

经机构伦理委员会（IEC 343-2018）批准后，根据（NCEP ATP-III）标准，年龄为45.0±7.6岁且患有代谢综合征的18位参与者（男性N = 4，女性N = 14）被纳入研究。 。参与者接受了为期12周的体育锻炼计划，其中包括根据GPAQ领域（工作，运输和娱乐）每周进行150分钟的中度至剧烈运动。在基线和12周后测量结局。

结果

在18名参与者中，分析了完成研究的10名参与者。十二周的体育锻炼显示出腰围（p = 0.047），餐后血糖（p = 0.0396），甘油三酸酯（p = 0.0323），体重指数（p = 0.0056），皮下脂肪（p = 0.0354）有显着变化和基础代谢率（p = 0.0035）。空腹血糖（p = 0.254），血脂谱（总胆固醇（p = 0.062）），高密度脂蛋白（p = 0.367），低密度脂蛋白（p = 0.641）和瘦素变化不明显（p= 0.328）。全球体育锻炼问卷显示出显着变化（p = 0.0254），表明体育锻炼行为发生了变化。

结论

从目前的研究得出的结论是，为期12周的体育锻炼促进计划带来了瘦素水平的微小变化，并具有改变代谢综合征参数和改善体育锻炼的潜力。