Plasmon-free surface-enhanced Raman scattering (SERS) substrates have attracted tremendous attention for their abundant sources, excellent chemical stability, superior biocompatibility, good signal uniformity, and unique selectivity to target molecules. Recently, researchers have made great progress in fabricating novel plasmon-free SERS substrates and exploring new enhancement strategies to improve their sensitivity. This review summarizes the recent developments of plasmon-free SERS substrates and specially focuses on the enhancement mechanisms and strategies. Furthermore, the promising applications of plasmon-free SERS substrates in biomedical diagnosis, metal ions and organic pollutants sensing, chemical and biochemical reactions monitoring, and photoelectric characterization are introduced. Finally, current challenges and future research opportunities in plasmon-free SERS substrates are briefly discussed.

无等离子体表面增强拉曼散射（SERS）底物因其丰富的来源，出色的化学稳定性，出色的生物相容性，良好的信号均匀性以及对目标分子的独特选择性而引起了极大的关注。最近，研究人员在制造新型无等离激元SERS底物和探索新的增强策略以提高其灵敏度方面取得了长足的进步。这篇综述总结了无等离激元SERS底物的最新发展，并特别着重于增强机制和策略。此外，介绍了无等离子体的SERS底物在生物医学诊断，金属离子和有机污染物感测，化学和生化反应监测以及光电表征中的有希望的应用。最后，