An impedance read-out circuit with high accuracy implemented using a TSMC 0.18 um mixed-signal CMOS process for BIA-type (bio-electrical impedance analysis) sensors to detect biomarkers is proposed in this investigation. In addition to proposing the impedance estimation circuit, the associated analytic proof is also disclosed. Using a high-order approximation model and high noise rejection capability by the addition of OPAs (operational amplifiers), the proposed system demonstrates a solution with high accuracy in terms of the maximum impedance error (\(\mathrm<\) 6 %) and the least phase error (\(\mathrm < \) 3\({^\circ }\)) in a frequency range from 1 kHz to 2 MHz.

在这项研究中，提出了一种高精度的阻抗读出电路，该电路使用TSMC 0.18 um混合信号CMOS工艺用于BIA型（生物电阻抗分析）传感器来检测生物标记。除了提出阻抗估计电路之外，还公开了相关的分析证明。通过添加OPA（运算放大器），使用高阶近似模型和高噪声抑制能力，所提出的系统在最大阻抗误差（\（\ mathrm <\） 6％）和在1 kHz至2 MHz的频率范围内的最小相位误差（\（\ mathrm <\） 3 \（{^ \ circ} \））。