Pulmonary hypertension (PH) is diagnosed invasively by right heart catheterization (RHC), which determines patient’s mean and systolic pulmonary artery pressure (mPAP, sPAP) and pulmonary vascular resistance (PVR). This study sought to identify non-invasive echocardiography parameters useful for screening PH. Patients (n=84; 19 normotensive; 17 pre-capillary PH; 48 post-capillary PH) who had undergone transthoracic Doppler echocardiography and RHC within 60 days of each other were identified. Tricuspid regurgitant (TR) jet velocities, velocity spectral densities, average flow rates, and Fourier transforms (FFT) of velocity waveforms were calculated via an in-house MATLAB code. Correlations were found between the FFT magnitude at 0 Hz and sPAP and mPAP for normotensive patients; between the MATLAB-calculated TR jet and sPAP and PVR for all PH patients; and between the sum of FFT magnitudes ≤2Hz and mPAP, sPAP, and PVR for post-capillary PH patients. Statistical difference was found between the FFT magnitudes at 2 Hz of pre- and post-capillary PH patients (p<0.05). These results suggest non-invasive parameters with clinical utility for estimating RHC measurements and discriminating between PH types, offering a path forward for less invasive and more accessible PH screening protocol.

中文翻译：

---

肺动脉高压患者多普勒超声心动图的回顾性计算机辅助图像分析

肺动脉高压 (PH) 是通过右心导管 (RHC) 侵入性诊断的，它确定患者的平均和收缩期肺动脉压 (mPAP, sPAP) 和肺血管阻力 (PVR)。本研究旨在确定可用于筛查 PH 的非侵入性超声心动图参数。耐心 （n=84; 19 血压正常；17 预毛细管 PH；确定了 48 名在 60 天内接受了经胸多普勒超声心动图和 RHC 的毛细血管后 PH)。通过内部 MATLAB 代码计算三尖瓣反流 (TR) 射流速度、速度谱密度、平均流速和速度波形的傅里叶变换 (FFT)。发现 0 Hz 时的 FFT 幅度与血压正常患者的 sPAP 和 mPAP 之间存在相关性；MATLAB 计算的 TR 射流与所有 PH 患者的 sPAP 和 PVR 之间；和 FFT 幅度之和之间≤2毛细血管后 PH 患者的 Hz 和 mPAP、sPAP 和 PVR。发现毛细血管前和后毛细血管 PH 患者在 2 Hz 处的 FFT 幅度之间存在统计学差异（p<0.05）。这些结果表明具有临床实用性的非侵入性参数可用于估计 RHC 测量值和区分 PH 类型，为侵入性更小、更容易获得的 PH 筛查方案提供了一条前进的道路。