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An Updated Review of Secondary Metabolites from Marine Fungi
Mini-Reviews in Medicinal Chemistry ( IF 3.3 ) Pub Date : 2021-05-01 , DOI: 10.2174/1389557520666200925142514
Syed Shabana 1 , K. Rajya Lakshmi 1 , A. Krishna Satya 1
Affiliation  

Marine fungi are valuable and richest sources of novel natural products for medicinal and pharmaceutical industries. Nutrient depletion, competition or any other type of metabolic stress which limits marine fungal growth promotes the formation and secretion of secondary metabolites. Generally secondary metabolites can be produced by many different metabolic pathways and include antibiotics, cytotoxic and cyto-stimulatory compounds. Marine fungi produce many different types of secondary metabolites that are of commercial importance. This review paper deals with around 187 novel compounds and 212 other known compounds with anticancer and antibacterial activities with a special focus on the period from 2011-2019. Furthermore, this review highlights the sources of organisms, chemical classes and biological activities (anticancer and antibacterial) of metabolites, that were isolated and structurally elucidated from marine fungi to throw a helping hand for novel drug development.



中文翻译:

海洋真菌次级代谢产物的最新综述

海洋真菌是药用和制药工业中新颖天然产物的宝贵且最丰富的来源。营养物质的消耗,竞争或限制海洋真菌生长的任何其他类型的代谢应激都会促进次生代谢产物的形成和分泌。通常,次级代谢产物可以通过许多不同的代谢途径产生,包括抗生素,细胞毒性和细胞刺激性化合物。海洋真菌产生许多不同类型的具有商业重要性的次级代谢产物。这篇综述文章涉及约187种具有抗癌和抗菌活性的新化合物和212种其他已知化合物,特别关注2011-2019年。此外,这篇评论重点介绍了生物体的来源,

更新日期:2021-03-08
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