Kümmell disease (KD) causes serious vertebral body collapse in patients. However, only a few case reports have been conducted and the number of patients with KD investigated was limited. Additionally, the frequently used poly(methyl methacrylate) (PMMA) bone cement for KD is limited by excessive modulus and poor biocompatibility. Herein, we aimed to modify PMMA bone cement with mineralized collagen (MC), and compare the clinical effects, image performance and finite element analysis between the modified bone cement and PMMA bone cement for the treatment of phase I and II KD. Thirty-nine KD patients treated with PMMA bone cement and 40 KD patients treated with MC-modified PMMA bone cement from June 2015 to March 2017 were retrospectively analyzed. The surgical procedure, intraoperative blood loss, hospital stay and complications were compared between different groups. Visual analog scale, Oswestry disability index, anterior vertebral height, posterior vertebral height, computed tomography value, adjacent vertebral re-fracture, Cobb angle and wedge-shaped correction angle were evaluated. Additionally, the representative sample was selected for finite element analysis. We found that the MC-modified PMMA bone cement could achieve the same effect as that of PMMA bone cement and was associated with better vertebral height restoration in the long term.

中文翻译：

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改性聚甲基丙烯酸甲酯骨水泥治疗 Kümmell 病

Kümmell 病 (KD) 会导致患者出现严重的椎体塌陷。然而，仅进行了少数病例报告，调查的 KD 患者数量有限。此外，用于 KD 的常用聚甲基丙烯酸甲酯 (PMMA) 骨水泥受到模量过高和生物相容性差的限制。在此，我们旨在用矿化胶原蛋白 (MC) 改性 PMMA 骨水泥，并比较改性骨水泥和 PMMA 骨水泥治疗 I 期和 II 期 KD 的临床效果、图像性能和有限元分析。回顾性分析2015年6月至2017年3月使用PMMA骨水泥治疗的39例KD患者和使用MC改性PMMA骨水泥治疗的40例KD患者。手术过程、术中失血、比较不同组的住院时间和并发症。评估视觉模拟量表、Oswestry 残疾指数、前椎高度、后椎高度、计算机断层扫描值、相邻椎体再骨折、Cobb 角和楔形矫正角。此外，选择具有代表性的样本进行有限元分析。我们发现 MC 改性 PMMA 骨水泥可以达到与 PMMA 骨水泥相同的效果，并且从长远来看与更好的椎体高度恢复相关。选取具有代表性的样本进行有限元分析。我们发现 MC 改性 PMMA 骨水泥可以达到与 PMMA 骨水泥相同的效果，并且从长远来看与更好的椎体高度恢复相关。选取具有代表性的样本进行有限元分析。我们发现 MC 改性 PMMA 骨水泥可以达到与 PMMA 骨水泥相同的效果，并且从长远来看与更好的椎体高度恢复相关。