Since the early 20 th century, progress in cancer therapies has significantly improved disease prognosis. Nonetheless, cancer treatments are often associated with side effects that can negatively affect patient wellbeing and disrupt the course of treatment. Among the main side effects, taste impairment is associated with depression, malnutrition and morbid weight loss. Although relatively common, taste disruption associated with cancer therapies remains poorly understood. Here, we review the current knowledge related to the molecular mechanisms underlying taste maintenance and disruption in the context of cancer therapies.

中文翻译：

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癌症治疗中味蕾维持和损害的机制概述

自 20 世纪初以来，癌症治疗的进展显着改善了疾病的预后。尽管如此，癌症治疗通常与副作用有关，这些副作用会对患者的健康产生负面影响并扰乱治疗过程。在主要副作用中，味觉障碍与抑郁、营养不良和病态体重减轻有关。虽然相对常见，但与癌症治疗相关的味觉破坏仍然知之甚少。在这里，我们回顾了与癌症治疗背景下味觉维持和破坏的分子机制相关的当前知识。