Effectively achieving wound healing is a great challenge. Herein, we facilely prepared temperature-responsive MXene nanobelt fibers (T-RMFs) carrying vitamin E with a controllable release ability for wound healing. These T-RMFs were composed of MXene nanosheets spread along polyacrylonitrile and polyvinylpyrrolidone composite nanobelts together with a thermosensitive PAAV- coating layer. The high mass loading and high surface area of the MXene nanosheets endow the T-RMFs with excellent photothermal properties. The temperature could be easily controlled by near-infrared (NIR) irradiation exposure, and then the thermoresponsive polymeric coating layer relaxed the interface to dissolve vitamin E and promote vitamin E release. The T-RMFs demonstrated excellent biocompatibility and wound-healing functions in cellular and animal tests. The facile method, high mass loading, high surface area, excellent wound-healing functions, interesting nanosheet/nanobelt structure, mass production potential, and NIR responsive properties of these T-RMFs indicate the great potential of our nanobelts for wound healing, tissue engineering, and much broader application areas. This facile nanosheet/nanobelt preparation strategy paves a new way for nanomaterial fabrication and applications.

有效地实现伤口愈合是巨大的挑战。在本文中，我们轻松地制备了具有维生素E的温度响应性MXene纳米带纤维（T-RMFs），该纤维具有可控制的伤口愈合释放能力。这些T-RMF由沿着聚丙烯腈和聚乙烯吡咯烷酮复合纳米带分布的MXene纳米片以及热敏PAAV涂层组成。MXene纳米片的高质量负载和高表面积赋予T-RMF优异的光热性能。可以通过近红外（NIR）辐射曝光轻松控制温度，然后热响应性聚合物涂层松弛界面以溶解维生素E和促进维生素E释放。T-RMFs在细胞和动物试验中表现出出色的生物相容性和伤口愈合功能。简便的方法 这些T-RMF的高质量负载，高表面积，出色的伤口愈合功能，有趣的纳米片/纳米纤维结构，潜在的生产潜力以及NIR响应特性表明，我们的纳米带在伤口愈合，组织工程以及更广泛的领域具有巨大的潜力应用领域。这种简便的纳米片/纳米晶制备策略为纳米材料的制造和应用开辟了一条新途径。