Antivirulence therapy has proven to be an attractive method for the treatment of bacterial infections and venomous injuries; however, the approaches for neutralizing multiple types of virulence through one platform are limited. To address this challenge, we have developed a reactive conjugated polymer, PPV–NHS, which functions as a broad-spectrum antidote for directly inactivating basic toxins. The antivirulence is achieved via multivalent electrostatic recognition and subsequent amidation reactions between PPV–NHS and toxins. The resultant bioconjugates significantly reduced neurotoxicity and cytotoxicity. In the mouse model, PPV–NHS effectively inhibited the toxicity of cardiotoxin (CTX) and improved the survival rate of toxin-challenged mice. This work represents the rational design of functionalized conjugated polymers for antivirulence therapy with both high efficiency and broad applicability.

事实证明，抗病毒治疗是治疗细菌感染和毒伤的一种有吸引力的方法。但是，通过一个平台中和多种类型的毒力的方法受到限制。为了应对这一挑战，我们开发了一种反应性共轭聚合物PPV-NHS，它可以作为广谱解毒剂来直接使基本毒素失活。通过多价静电识别以及随后PPV-NHS与毒素之间的酰胺化反应可实现抗毒力。所得的生物缀合物显着降低了神经毒性和细胞毒性。在小鼠模型中，PPV–NHS有效抑制了心脏毒素（CTX）的毒性并提高了毒素攻击小鼠的存活率。