ABSTRACT

Rotaxanes can have topological isomers because of their mechanically interlocked axle and wheel components. Directional isomers are formed when the rotaxanes are constructed using an asymmetric axle and a three-dimensional non-symmetrical wheel. In this work, directional isomers of [2]rotaxanes were synthesised using lariat dibenzo-24-crown-8 ether as a non-symmetrical wheel component and a sec-ammonium salt axle. Control over the directional isomer ratio of [2]rotaxanes was achieved, as demonstrated by kinetic resolution via N-acetylation of the [2]rotaxanes.

中文翻译：

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带有套索冠醚轮的[2]轮烷定向异构体的合成和动力学拆分

摘要

轮烷可能具有拓扑异构体，因为它们具有机械互锁的轴和轮组件。当使用不对称轴和三维非对称轮构建轮烷时，会形成定向异构体。在这项工作中，使用套索二苯并-24-冠-8 醚作为非对称轮组件和仲铵盐轴合成了 [2] 轮烷的定向异构体。实现了对 [2] 轮烷的定向异构体比例的控制，如通过[2] 轮烷的N-乙酰化的动力学拆分所证明的。