ABSTRACT

Upon Seeking natural and safe alternatives for synthetic medicines to treat many chronic diseases, seaweeds have offered a promising resource to produce numerous bioactive secondary metabolites. Through in vivo investigations, Turbinaria decurrens acetone extract (AE) revealed its antidiabetic activity against alloxan-induced diabetic rats. Treatment of rats with T. decurrens AE at 300 and 150 mg/Kg doses revealed antihyperglycemic activity by reducing the elevated blood glucose level. A remarkable decrease in the liver, kidney functions, and hyperlipidemia related to diabetes were also detected. Administration of the same extract also showed a recovery in body weight loss, total protein, albumin, and haemoglobin levels compared with untreated diabetic rats. Furthermore, treatment of rats with the same extract improved liver and pancreas histopathological disorders related to diabetes. These effects may be attributed to the presence of bioactive phytochemicals and antioxidant components in T. decurrens AE mainly cyclotrisiloxane, hexamethyl, and cyclic diterpene 3,7,11,15-tetramethyl-2-hexadecen-1-ol (phytol alcohol). Besides, other valuable secondary metabolites, as phenols, flavonoids, alkaloids, terpenoids, steroid and glycosides, which were documented and published by the same authors in a previous study. The obtained results in the present study recommended using T. decurrens AE in developing medicinal preparations for treatment of diabetes and its related symptoms.

摘要

在为治疗许多慢性疾病寻找合成药物的天然和安全替代品时，海藻提供了一种有希望的资源来生产许多具有生物活性的次级代谢物。通过体内研究，Turbinaria decurrens丙酮提取物 (AE) 揭示了其对四氧嘧啶诱导的糖尿病大鼠的抗糖尿病活性。用T. decurrens治疗大鼠300 和 150 mg/Kg 剂量的 AE 通过降低升高的血糖水平显示出抗高血糖活性。还检测到与糖尿病相关的肝、肾功能和高脂血症显着下降。与未治疗的糖尿病大鼠相比，施用相同的提取物还显示出体重减轻、总蛋白、白蛋白和血红蛋白水平的恢复。此外，用相同的提取物治疗大鼠可改善与糖尿病相关的肝脏和胰腺组织病理学疾病。这些影响可能归因于T. decurrens中存在生物活性植物化学物质和抗氧化成分AE主要是环三硅氧烷、六甲基和环状二萜3,7,11,15-四甲基-2-十六碳烯-1-醇（植醇）。此外，其他有价值的次级代谢物，如酚类、类黄酮、生物碱、萜类化合物、类固醇和糖苷，由同一作者在先前的研究中记录和发表。本研究获得的结果推荐使用T. decurrens AE 开发用于治疗糖尿病及其相关症状的药物制剂。