Asymmetrical expression of alpha oscillations in the frontal cortex, increased left relative to right, is a phenotype associated with increased behavioral inhibition and mood-related psychiatric illnesses. However, investigations of frontal alpha asymmetry in mood-disorders have yielded inconsistent findings. A better understanding of factors that contribute to individual differences is required to establish a useful biomarker for the diagnosis and treatment of mood and stress related disorders. A novel factor is hormone concentration, as steroid hormones play a prominent role in regulating mood and stress. To investigate this question, concentrations of testosterone and estradiol were sampled. Multiple linear regression revealed that low levels of testosterone correlated with greater frontal alpha asymmetry in women. Source localization found that frontal asymmetry was driven by decreased alpha power in right inferior frontal gyrus that correlated with increased behavioral inhibition in women. Together, these findings might explain inconsistencies in previous investigation on frontal alpha asymmetry.

额叶皮质中 α 振荡的不对称表达，左相对于右增加，是一种与行为抑制增加和情绪相关的精神疾病相关的表型。然而，对情绪障碍中额叶 α 不对称性的研究得出了不一致的结果。需要更好地了解导致个体差异的因素，以建立用于诊断和治疗情绪和压力相关疾病的有用生物标志物。一个新的因素是激素浓度，因为类固醇激素在调节情绪和压力方面发挥着重要作用。为了研究这个问题，我们对睾酮和雌二醇的浓度进行了采样。多元线性回归显示，低水平的睾酮与女性更大的额叶 α 不对称相关。源定位发现，额叶不对称是由右额下回的阿尔法功率降低驱动的，这与女性的行为抑制增加有关。总之，这些发现可能解释了先前关于额叶 alpha 不对称性的调查中的不一致之处。