The European Physical Journal E ( IF 1.8 ) Pub Date : 2021-03-08 , DOI: 10.1140/epje/s10189-021-00028-7 Kuheli Biswas 1 , Anandamohan Ghosh 1
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Abstract
The post-transcriptional regulation of a protein by multiple small RNA molecules has been formulated as a stochastic process. An approximate solution of the master equation shows that the protein statistics can exhibit a generic form applicable for many regulatory scenarios. The first passage time (FPT) statistics has been obtained for regulation by single sRNA, with negative and positive regulations as limiting cases, as well as regulation by multiple sRNAs. The multiple sRNAs are able to independently control protein mean and variance, and we show that this is an advantageous mechanism to control FPT fluctuations in order to improve timing efficiency in post-transcriptional regulation.
Graphic Abstract
中文翻译：
多个小 RNA 转录后调控的首次通过时间
摘要
多个小 RNA 分子对蛋白质的转录后调节已被制定为一个随机过程。主方程的近似解表明蛋白质统计可以展示适用于许多监管场景的通用形式。首次通过时间（FPT）统计已获得单个 sRNA 调控，负调控和正调控为限制情况，以及多个 sRNA 调控。多个 sRNA 能够独立控制蛋白质均值和方差，我们表明这是控制 FPT 波动以提高转录后调节时间效率的有利机制。
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