In this study, vapor recompression and heat integration assisted distillation arrangements with either the low or high pressure in the reflux drum are proposed to reduce and/or eliminate the application of the costly refrigerant for the separation of n-heptane and isobutanol mixture. The high-pressure arrangement with vapor recompression and heat integration is the most attractive among these four intensified configurations since it can reduce total annual cost by 18.10%, CO₂ emissions by 75.01% based on natural gas (78.78% based on heavy oil fuel), and second-law efficiency by 61.20% compared to a conventional refrigerated distillation system. Furthermore, exergy destruction in each component is calculated for the heat integration configurations and is shown in pie diagrams. The results demonstrate that the high-pressure configuration presents unique advantages in terms of thermodynamic efficiency compared to the low-pressure case. In addition, dynamic control investigation is performed for the economically efficient arrangement and good product compositions are well controlled through a dual-point temperature control strategy with almost negligible product offsets and quick process responses when addressing 20% step changes in production rate and feed composition. Note that there are no composition measurement loops in our developed control schemes.

在该研究中，提出了在回流鼓中具有低压或高压的蒸气再压缩和热集成辅助蒸馏装置，以减少和/或消除昂贵的制冷剂在正庚烷和异丁醇混合物分离中的应用。具有蒸汽压缩和热集成的高压装置是这四种强化配置中最有吸引力的，因为它可以将每年的总成本降低18.10％，CO ₂与传统的冷冻蒸馏系统相比，天然气的总排放量降低了75.01％（重油燃料的降低了78.78％），二次法效率提高了61.20％。此外，针对热集成配置计算了每个组件的火用破坏，并在饼图中显示。结果表明，与低压情况相比，高压配置在热力学效率方面显示出独特的优势。此外，对经济有效的装置进行了动态控制研究，并通过双点温度控制策略很好地控制了良好的产品组成，当解决生产率和进料组成的20％阶跃变化时，产品偏移几乎可以忽略不计，并且工艺响应迅速。