Surgery holds the best outcomes for drug-resistant epilepsy in children, making localization of a seizure focus essential. However, there is limited research on the contribution of magnetoencephalography and single-photon emission computed tomography (SPECT) to the presurgical evaluation of lesional and nonlesional pediatric patients. This study proposed to evaluate the concordance of SPECT and magnetoencephalography (MEG) to scalp electroencephalography (EEG) to determine their effective contribution to the presurgical evaluation. On review, MEG and SPECT studies for 28 drug-resistant epilepsy cases were completed at Children’s Hospital of Pittsburgh from May 2012 to August 2018. Although not reaching statistical significance, MEG had increased lobar concordance with EEG compared with SPECT (68% vs 46%). MEG or SPECT results effectively provided localization data leading to 6 surgical evaluations and 3 resections with outcomes of Engel class I or II at 12 months. This study suggests MEG and SPECT provide valuable localizing information for presurgical epilepsy evaluation of children with drug-resistant epilepsy.

手术对儿童耐药性癫痫的治疗效果最好，因此癫痫病灶的定位至关重要。然而，关于脑磁图和单光子发射计算机断层扫描 (SPECT) 对病变和非病变儿科患者术前评估的贡献的研究有限。本研究建议评估 SPECT 和脑磁图 (MEG) 与头皮脑电图 (EEG) 的一致性，以确定它们对术前评估的有效贡献。经过回顾，2012 年 5 月至 2018 年 8 月在匹兹堡儿童医院完成了对 28 例耐药性癫痫病例的 MEG 和 SPECT 研究。虽然没有达到统计学意义，但与 SPECT 相比，MEG 与 EEG 的脑叶一致性增加（68% vs 46% ）。MEG 或 SPECT 结果有效地提供了定位数据，导致 6 次手术评估和 3 次切除，结果在 12 个月时恩格尔 I 级或 II 级。这项研究表明 MEG 和 SPECT 为耐药性癫痫儿童的术前癫痫评估提供了有价值的定位信息。