RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes,Cell Proliferation

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RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-03-05 , DOI: 10.1111/cpr.13000
Qing Xia _{1,

2,

3,

4,

5} , Guizhong Cui ₃ , Ye Fan ₆ , Xiuqin Wang _{1,

2,

3,

4} , Gongcheng Hu _{1,

2,

3,

4} , Lisha Wang _{1,

2,

3,

4} , Xi Luo _{1,

2,

3,

4} , Lele Yang _{1,

2,

3,

4} , Qingqing Cai ₁ , Kaibiao Xu _{1,

2,

3,

4} , Wenjing Guo ₁ , Minghui Gao ₁ , Yingying Li ₃ , Ji Wu ₇ , Wei Li ₈ , Jiayu Chen ₉ , Huayu Qi _{1,

2,

3,

5} , Guangdun Peng _{1,

2,

3,

4,

5} , Hongjie Yao _{1,

2,

3,

4,

5}

Affiliation

CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, China.
GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Bioland Laboratory (Guangzhou Regenerative Medicine and Health GuangDong Laboratory), Guangzhou, China.
Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Department of Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, China.
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Clinical and Translation Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Mammalian spermatogenesis is a biological process of male gamete formation. Gonocytes are the only precursors of spermatogonial stem cells (SSCs) which develop into mature spermatozoa. DDX5 is one of DEAD‐box RNA helicases and expresses in male germ cells, suggesting that Ddx5 plays important functions during spermatogenesis. Here, we explore the functions of Ddx5 in regulating the specification of gonocytes.

中文翻译：

RNA解旋酶DDX5是新生小鼠性母细胞存活的关键调节因子

哺乳动物精子发生是雄配子形成的生物学过程。生殖母细胞是精原干细胞（SSC）的唯一前体，可发育成成熟精子。 DDX5 是 DEAD-box RNA 解旋酶之一，在雄性生殖细胞中表达，表明Ddx5在精子发生过程中发挥重要作用。在这里，我们探讨了Ddx5在调节生殖细胞规格中的功能。

更新日期：2021-05-02

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