RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes,Cell Proliferation

当前位置： X-MOL 学术 › Cell Prolif. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes
Cell Proliferation ( IF 8.5 ) Pub Date : 2021-03-05 , DOI: 10.1111/cpr.13000
Qing Xia _{1,

2,

3,

4,

5} , Guizhong Cui ₃ , Ye Fan ₆ , Xiuqin Wang _{1,

2,

3,

4} , Gongcheng Hu _{1,

2,

3,

4} , Lisha Wang _{1,

2,

3,

4} , Xi Luo _{1,

2,

3,

4} , Lele Yang _{1,

2,

3,

4} , Qingqing Cai ₁ , Kaibiao Xu _{1,

2,

3,

4} , Wenjing Guo ₁ , Minghui Gao ₁ , Yingying Li ₃ , Ji Wu ₇ , Wei Li ₈ , Jiayu Chen ₉ , Huayu Qi _{1,

2,

3,

5} , Guangdun Peng _{1,

2,

3,

4,

5} , Hongjie Yao _{1,

2,

3,

4,

5}

Affiliation

CAS Key Laboratory of Regenerative Biology and Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine Joint School of Life Sciences Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Medical University Guangzhou China
GIBH‐HKU Guangdong‐Hong Kong Stem Cell and Regenerative Medicine Research Centre Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China
Bioland Laboratory (Guangzhou Regenerative Medicine and Health GuangDong Laboratory) Guangzhou China
Institute of Stem Cell and Regeneration Chinese Academy of Sciences Beijing China
University of Chinese Academy of Sciences Beijing China
Department of Respiratory Disease Xinqiao Hospital Third Military Medical University Chongqing China
Bio‐X Institutes Shanghai Jiao Tong University Shanghai China
State Key Laboratory of Stem Cell and Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing China
Clinical and Translation Research Center of Shanghai First Maternity and Infant Hospital Shanghai Key Laboratory of Signaling and Disease Research School of Life Sciences and Technology Tongji University Shanghai China

Mammalian spermatogenesis is a biological process of male gamete formation. Gonocytes are the only precursors of spermatogonial stem cells (SSCs) which develop into mature spermatozoa. DDX5 is one of DEAD‐box RNA helicases and expresses in male germ cells, suggesting that Ddx5 plays important functions during spermatogenesis. Here, we explore the functions of Ddx5 in regulating the specification of gonocytes.

中文翻译：

RNA解旋酶DDX5作为新生小鼠角质细胞存活的关键调节剂

哺乳动物的精子发生是雄配子形成的生物学过程。促性腺细胞是发育成成熟精子的精原干细胞（SSC）的唯一前体。DDX5是DEAD-box RNA解旋酶之一，在雄性生殖细胞中表达，这表明Ddx5在精子发生过程中起着重要的作用。在这里，我们探讨了Ddx5在调节性腺细胞规范中的功能。

更新日期：2021-05-02

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>