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N-acylethanolamine-hydrolysing acid amidase: A new potential target to treat paclitaxel-induced neuropathy
European Journal of Pain ( IF 3.6 ) Pub Date : 2021-03-06 , DOI: 10.1002/ejp.1758
Wisam Toma 1 , Martial Caillaud 1 , Nipa H Patel 1 , Tammy H Tran 1 , Giulia Donvito 2 , Jane Roberts 1 , Deniz Bagdas 3 , Asti Jackson 3 , Aron Lichtman 1, 4 , David A Gewirtz 1 , Alexandros Makriyannis 5 , Michael S Malamas 5 , M Imad Damaj 1, 6
Affiliation  

Although paclitaxel is an effective chemotherapeutic agent used to treat multiple types of cancer (e.g. breast, ovarian, neck and lung), it also elicits paclitaxel-induced peripheral neuropathy (PIPN), which represents a major dose-limiting side effect of this drug.

中文翻译:

N-酰基乙醇胺水解酸酰胺酶:治疗紫杉醇诱导的神经病变的新潜在靶点

尽管紫杉醇是一种有效的化学治疗剂,用于治疗多种类型的癌症(例如乳腺癌、卵巢癌、颈癌和肺癌),但它也会引发紫杉醇诱导的周围神经病变 (PIPN),这是该药物的主要剂量限制性副作用。
更新日期:2021-03-06
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