In this overview, we explore the electroanalytical determination of theophylline. Theophylline finds use as a bronchodilator for treating diseases such as asthma and chronic obstructive pulmonary disease (COPD). There is a need to measure the concentration of theophylline in pharmaceuticals for QA/QC purposes as well as in plasma samples to ensure the doses of theophylline are at the correct therapeutic levels. If the concentration levels of theophylline deviate from the therapeutic levels (10–20 µg/mL for asthma), then patients can experience adverse effects. As such, there is a desire to progress from traditional laboratory based techniques to portable rapid testing. In this overview, we review the endeavours directed to the development of theophylline electroanalytical sensors, noting current and future trends.

在本概述中，我们探讨了茶碱的电分析测定。茶碱可作为支气管扩张药，用于治疗哮喘和慢性阻塞性肺疾病（COPD）等疾病。需要测量用于QA / QC目的的药物以及血浆样品中茶碱的浓度，以确保茶碱的剂量处于正确的治疗水平。如果茶碱的浓度水平偏离治疗水平（哮喘的浓度为10–20 µg / mL），则患者可能会出现不良反应。因此，期望从传统的基于实验室的技术发展到便携式快速测试。在本概述中，我们回顾了针对茶碱电分析传感器开发的努力，并指出了当前和未来的趋势。