Infrared absorption spectroscopy has been used as part of a multi-technology approach implemented in a community drug checking project in Victoria, BC, Canada. As most synthetic opioids are either binary mixtures of fentanyl and caffeine, or ternary mixtures of fentanyl with caffeine and a sugar alcohol, standards consisting of such mixtures have been prepared and were used to train a partial least squares regression model to quantify the fentanyl concentration in the mixture. Extensive details of the spectral pre-processing, and model development are provided. The model was then used to evaluate the fentanyl concentration of samples brought to the service by people who use drugs. This demonstrates that portable infrared absorption spectroscopy can be used not only to identify components in drug mixtures, but also to determine concentrations of fentanyl in complex mixtures as seen in illicit opioids.

红外吸收光谱已被用作加拿大卑诗省维多利亚市的社区药物检查项目中实施的多种技术方法的一部分。由于大多数合成阿片类药物是芬太尼和咖啡因的二元混合物，或芬太尼与咖啡因和糖醇的三元混合物，因此已制备了由此类混合物组成的标准品，并用于训练偏最小二乘回归模型来定量分析芬太尼中的芬太尼浓度。混合物。提供了光谱预处理和模型开发的大量详细信息。然后使用该模型评估使用毒品的人提供服务的样品中的芬太尼浓度。这表明便携式红外吸收光谱法不仅可以用于识别药物混合物中的成分，