Nano-graphene oxide (nGO), an effective drug nanocarrier, is used for simultaneous photothermal therapy (PTT) and near-infrared fluorescence imaging. Dacarbazine (DTIC) is used in the treatment of melanoma with limited clinical efficacy. PTT shows promise in the treatment of skin cancer. Herein, chitosan oligosaccharide (COS)-grafted nGO was further modified with CD47 antibody, and loaded DTIC was prepared using a versatile nanoplatform (nGO-COS-CD47/DTIC) for the treatment of melanoma as a synergistic targeted chemo-photothermal therapy. The in vitro results demonstrated that nGO-COS-CD47/DTIC nanocarriers have excellent biocompatibility, photothermal conversion efficiency, high targeting efficiency, fast drug release under NIR irradiation, and tumor cell killing efficiency. Notably, nGO-COS-CD47/DTIC plus NIR irradiation significantly promoted early cell apoptosis through the mitochondrial apoptosis pathway and exhibited a significant joint function of antitumor efficacy. The demonstrated nGO-COS-CD47/DTIC can provide a highly efficient malignant melanoma therapy using this multifunctional intelligent nanoplatform.

纳米氧化石墨烯（nGO）是一种有效的药物纳米载体，用于同时进行光热疗法（PTT）和近红外荧光成像。达卡巴嗪（DTIC）用于治疗黑色素瘤，临床疗效有限。PTT在皮肤癌的治疗中显示出希望。在本文中，用CD47抗体进一步修饰了壳聚糖寡糖（COS）接枝的nGO，并使用多功能纳米平台（nGO-COS-CD47 / DTIC）制备了负载的DTIC，用于治疗黑色素瘤，作为协同靶向化学光热疗法。体外结果表明，nGO-COS-CD47 / DTIC纳米载体具有优异的生物相容性，光热转化效率，高靶向效率，在NIR照射下快速释放药物和杀死肿瘤细胞的效率。尤其，nGO-COS-CD47 / DTIC加NIR辐射通过线粒体凋亡途径显着促进了早期细胞凋亡，并表现出显着的联合抗肿瘤功效。演示的nGO-COS-CD47 / DTIC可以使用这种多功能智能纳米平台提供高效的恶性黑色素瘤治疗。