Acute myeloid leukaemia (AML) is a very heterogeneous malignancy in which standard treatment is based on chemotherapy. Resistance to chemotherapeutic agents remains a big problem in AML, because negatively influences patient overall survival. Several resistance mechanisms have been described, the best of which is the process of drug removal from the cell and/or nucleus by membrane transport proteins. The aim of the study was to investigate the effect of polymorphism of genes coding ABCC3, GSTM5 involved in the transport and metabolism of drugs. For this purpose 95 newly diagnosed AML patients and 125 healthy controls were genotyped. We showed that ABCC3 rs4148405 and GSTM5 rs3754446, but not ABCC33 rs4793665, affected overall survival in Polish AML patients.

急性髓性白血病 (AML) 是一种异质性非常高的恶性肿瘤，其中标准治疗基于化学疗法。对化疗药物的耐药性仍然是 AML 中的一个大问题，因为它会对患者的总生存期产生负面影响。已经描述了几种耐药机制，其中最好的是通过膜转运蛋白从细胞和/或细胞核中去除药物的过程。该研究的目的是研究编码ABCC3、GSTM5的基因多态性对药物运输和代谢的影响。为此，对 95 名新诊断的 AML 患者和 125 名健康对照进行了基因分型。我们发现ABCC3 rs4148405 和GSTM5 rs3754446，但不是ABCC33 rs4793665，影响波兰 AML 患者的总生存期。