Antipsychotic polypharmacy (APP) is the concurrent use of more than one antipsychotic by a patient. Multiple antipsychotics are often prescribed, although all relevant guidelines discourage this practice. These recommendations are based on a lack of evidence for effectiveness and an increased risk of serious adverse events with APP. Studies on the effects of educational interventions targeted at physicians have demonstrated inconclusive results. Moreover, it is unclear how individualized these interventions need to be. In this study, we aimed to assess the effect of a general intervention and the additional impact of an individualized, prescriber-focused intervention on guidelines adherence, that is, the prescription of APP.

中文翻译：

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以个体化处方者为中心的反馈对减少住院患者抗精神病药复方用药的一般指南指导的附加影响。

抗精神病药联合用药 (APP) 是患者同时使用一种以上抗精神病药。尽管所有相关指南都不鼓励这种做法，但通常会开多种抗精神病药。这些建议是基于缺乏有效性证据和 APP 严重不良事件的风险增加。针对医生的教育干预效果的研究显示出不确定的结果。此外，尚不清楚这些干预措施需要多么个性化。在本研究中，我们旨在评估一般干预的效果以及个体化、以处方者为中心的干预对指南依从性（即 APP 处方）的额外影响。