Monitoring the gases released during breathing or via the skin has gained significance towards diagnosing diseases. In this study, a sensor chip capable of detecting nonanal gas, which is known to be a marker of lung cancer, was developed. The gas detection agent used was vanillin, which underwent aldol condensation with nonanal in the presence of a basic catalyst, resulting in the formation of an unsaturated aldehyde. Porous glass was used as the reaction field to carry the detection agent. Alkali-resistant porous glass was chosen because conventional porous glasses show low durabilities under basic conditions, as they primarily consist of SiO ₂ . Nonanal can be detected through changes in the absorption spectrum of the sensor. An accumulate-type sensor was used in this study, which exhibited a linear relationship between the degree of absorption changes at 470 nm and nonanal concentration in the 60 ppb–1.3 ppm range. Therefore, this biological marker gas sensor is effective for the early diagnosis of diseases. The alkali-resistant porous glass sensor chip exhibited a higher degree of absorption change than the conventional porous glass sensor chip.

中文翻译：

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使用耐碱多孔玻璃内部的醛醇缩合反应制备非肛门传感器

监测呼吸或皮肤中释放的气体对诊断疾病具有重要意义。在这项研究中，开发了一种能够检测壬二醛气体的传感器芯片，该芯片已知是肺癌的标志物。所用的气体检测剂是香草醛，其在碱性催化剂的存在下与壬醛进行醛醇缩合，导致形成不饱和醛。使用多孔玻璃作为反应场来携带检测剂。选择耐碱的多孔玻璃是因为常规的多孔玻璃在基本条件下显示出较低的耐久性，因为它们主要由SiO ₂组成 。可以通过传感器吸收光谱的变化来检测壬醛。在这项研究中使用了一种累积型传感器，该传感器在470 nm处的吸收变化程度与60 ppb–1.3 ppm范围内的壬二醛浓度之间呈线性关系。因此，该生物标记气体传感器对于疾病的早期诊断是有效的。与传统的多孔玻璃传感器芯片相比，耐碱多孔玻璃传感器芯片表现出更高的吸收变化程度。