A practical approach toward the synthesis of 2-arylazoles via direct arylation is described. The transformation relies on a Pd/Cu cocatalyst system that operates with low catalyst loadings. The reaction conditions were found to be tolerant of a wide range of functional groups and nitrogen-containing heterocycles commonly employed in a drug discovery setting.

中文翻译：

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Pd / Cu双重催化实现的腈直接芳基化

描述了一种通过直接芳基化合成2-芳基唑的实用方法。该转化依赖于在低催化剂负载下运行的Pd / Cu助催化剂体系。发现反应条件耐受在药物发现环境中通常使用的各种官能团和含氮杂环。