Deep vein thrombosis has been recognised as a complication of antipsychotic treatment and is reported to be more common with atypical antipsychotics. Risperidone is a second-generation atypical antipsychotic and there have been case reports of risperidone-associated deep vein thrombosis, most of them reporting the complication from 2 weeks to a few months of initiation of therapy. Here, we are reporting a case of deep vein thrombosis in a male patient in his early forties with paranoid schizophrenia, which presented on the fourth day of starting risperidone therapy. This case is being reported to highlight the fact that deep vein thrombosis can occur as early as fourth day of initiation of risperidone therapy, that too at a low dose (2 mg/day). The case also emphasises the importance of monitoring these patients for this rare but potentially serious adverse effect from the first day itself after initiation of a new antipsychotic.

中文翻译：

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利培酮治疗第四天深静脉血栓形成

深静脉血栓形成已被认为是抗精神病药物治疗的并发症，据报道在使用非典型抗精神病药物时更常见。利培酮是第二代非典型抗精神病药物，已有与利培酮相关的深静脉血栓形成的病例报告，其中大多数报告的并发症发生在开始治疗的 2 周至几个月内。在这里，我们报告了一名 40 岁出头的偏执型精神分裂症男性患者的深静脉血栓形成病例，该患者在开始利培酮治疗的第四天出现。该病例的报道强调了一个事实，即深静脉血栓形成早在开始利培酮治疗的第四天就可能发生，即使是在低剂量（2 毫克/天）的情况下也是如此。