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The impact of paternal alcohol, tobacco, caffeine use and physical activity on offspring mental health: A systematic review and meta-analysis
medRxiv - Epidemiology Pub Date : 2021-03-05 , DOI: 10.1101/2021.03.02.21252760
Kayleigh E Easey , Gemma C Sharp

Background: There is some evidence that paternal health behaviours during and around pregnancy could be associated with offspring health outcomes. However, the impact that paternal health behaviours during pregnancy can have on offspring mental health is understudied and remains unclear. Methods: We conducted a systematic review and meta-analysis of articles in PubMed describing studies of potentially modifiable paternal health behaviours (tobacco smoking, alcohol consumption, caffeine consumption and physical activity) in the prenatal period in relation to offspring mental health. Results: Ten studies were included and categorized by paternal health behaviour and offspring mental health outcome investigated. The narrative synthesis provided evidence of association between paternal health behaviours around pregnancy and offspring mental health problems, with the strongest evidence shown for tobacco use. Grouped by analysis type, two separate meta-analyses showed evidence of paternal smoking during pregnancy being associated with greater odds of ADHD in offspring (OR 1.42, 95% CI 1.02 to 1.99; HR 1.28, 95% CI 1.19 to 1.39). Conclusions: Our review suggests that paternal tobacco smoking and alcohol consumption in the prenatal period are associated with poorer offspring mental health, particularly hyperactivity/ADHD. Future investigation using methods that allow stronger causal inference is needed to further investigate if these associations are causal.

中文翻译:

父亲饮酒,吸烟,使用咖啡因和体育锻炼对后代心理健康的影响:系统评价和荟萃分析

背景:有证据表明,怀孕期间和怀孕前后的父亲健康行为可能与后代健康状况有关。但是,怀孕期间父亲的健康行为对后代心理健康的影响尚未得到充分研究,目前尚不清楚。方法:我们对PubMed中的文章进行了系统的回顾和荟萃分析,描述了产前时期与后代心理健康相关的潜在可改变的父亲健康行为(吸烟,饮酒,咖啡因和身体活动)的研究。结果:纳入十项研究,并按父亲的健康行为和所调查的后代心理健康结果进行分类。叙述性综合提供了怀孕前后的父亲健康行为与后代精神健康问题之间关联的证据,其中最强有力的证据表明使用了烟草。按分析类型分组,两个单独的荟萃分析显示,怀孕期间父亲吸烟与后代多动症患病几率增加相关(OR 1.42,95%CI 1.02至1.99; HR 1.28,95%CI 1.19至1.39)。结论:我们的评论表明,产前时期的父亲吸烟和饮酒与后代心理健康状况较差有关,特别是多动症/ ADHD。需要进一步使用允许更强的因果推断的方法进行调查,以进一步研究这些关联是否为因果关系。两项单独的荟萃分析显示,怀孕期间父亲吸烟与后代多动症患病几率增加相关(OR 1.42,95%CI 1.02至1.99; HR 1.28,95%CI 1.19至1.39)。结论:我们的评论表明,产前时期的父亲吸烟和饮酒与后代心理健康状况较差有关,特别是多动症/ ADHD。需要进一步使用允许更强的因果推断的方法进行调查,以进一步研究这些关联是否为因果关系。两项单独的荟萃分析显示,怀孕期间父亲吸烟与后代多动症患病几率增加相关(OR 1.42,95%CI 1.02至1.99; HR 1.28,95%CI 1.19至1.39)。结论:我们的评论表明,产前时期的父亲吸烟和饮酒与后代心理健康状况较差有关,特别是多动症/ ADHD。需要进一步使用允许更强的因果推断的方法进行调查,以进一步研究这些关联是否为因果关系。我们的评论表明,产前时期的父亲吸烟和饮酒与后代心理健康状况较差有关,尤其是多动症/ ADHD。需要进一步使用允许更强的因果推断的方法进行调查,以进一步研究这些关联是否为因果关系。我们的评论表明,产前时期的父亲吸烟和饮酒与后代心理健康状况较差有关,尤其是多动症/ ADHD。需要进一步使用允许更强的因果推断的方法进行调查,以进一步研究这些关联是否为因果关系。
更新日期:2021-03-05
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