In real music, the original melody may appear intact, with little elaboration only, or significantly modified. Since a melody is most easily perceived in music, hearing significantly modified melody may change a brain connectivity. Mozart KV 265 is comprised of a theme with an original melody of "Twinkle Twinkle Little Star" and its significant variations. We studied whether effective connectivity changes with significantly modified melody, between bilateral inferior frontal gyri (IFGs) and Heschl's gyri (HGs) using magnetoencephalography (MEG). Among the 12 connectivities, the connectivity from the left IFG to the right HG was consistently increased with significantly modified melody compared to the original melody in 2 separate sets of the same rhythmic pattern with different melody (p = 0.005 and 0.034, Bonferroni corrected). Our findings show that the modification of an original melody in a real music changes the brain connectivity.

中文翻译：

---

通过修改真实音乐中的旋律来增加额颞连接

在真实的音乐中，原始的旋律可能看起来完整无缺，仅需很少的修饰，或进行了明显的修改。由于旋律在音乐中最容易察觉，因此听到明显改变的旋律可能会改变大脑的连接性。莫扎特KV 265的主题是原始旋律“ Twinkle Twinkle Little Star”及其重大变化。我们使用磁脑电图（MEG）研究了双侧下额回（IFG）和赫氏回（HG）之间有效的连接性是否随着显着改变的旋律而改变。在12个连接中，与原始乐曲相比，从左IFG到右HG的连接性在原始旋律中得到了持续改善，与原始旋律相比，在两组具有不同旋律的相同节奏模式中（p = 0.005和0.034，Bonferroni进行了校正）。