Clostridium perfringens is an anaerobic, gram-positive, spore-forming bacterium that ubiquitously inhabits a wide variety of natural environments including the gastrointestinal tract of humans and animals. C. perfringens is an opportunistic enteropathogen capable of producing at least 20 different toxins in various combinations. Strains of C. perfringens are currently categorized into seven toxinotypes (A, B, C, D, E, F & G) based on the presence/absence of four major toxins (alpha, beta, epsilon & iota) and two minor toxins (enterotoxin & netB). Each toxinotype is associated with specific histotoxic and enteric diseases. The Quality Assurance Laboratory (QAL) at the National Institute of Environmental Health Sciences (NIEHS) screens incoming animal feeds for aerobic, enteric pathogens, such as Salmonella spp. and E. coli. Recently, QAL has incorporated anaerobic screening of incoming animal feeds. To date, the lab has isolated numerous Clostridium species, including C. perfringens, from 23 lots of natural-ingredient laboratory animal diets.

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从天然成分实验动物饮食中分离到产气荚膜梭菌菌株的产毒特性

产气荚膜梭状芽胞杆菌是一种厌氧，革兰氏阳性，可形成孢子的细菌，普遍存在于各种自然环境中，包括人和动物的胃肠道。产气荚膜梭菌是一种机会性肠病原体，能够以各种组合产生至少20种不同的毒素。目前，产气荚膜梭菌菌株根据是否存在四种主要毒素（α，β，ε和iota）和两种次要毒素（（A，B，C，D，E，F和G）分为7种毒素型（A，B，C，D，E，F和G）。肠毒素和netB）。每种毒素型都与特定的组织毒性和肠道疾病有关。美国国家环境健康科学研究所（NIEHS）的质量保证实验室（QAL）筛选传入的动物饲料中是否含有需氧，肠道病原体，例如沙门氏菌。和大肠杆菌。最近，QAL已对进来的动物饲料进行厌氧筛选。迄今为止，该实验室已从23种天然成分实验室动物饮食中分离出多种梭菌，包括产气荚膜梭菌。