Label Free Quantification (LFQ) of shotgun proteomics data is a popular and robust method for the characterization of relative protein abundance between samples. Many analytical pipelines exist for the automation of this analysis and some tools exist for the subsequent representation and inspection of the results of these pipelines. Mass Dynamics 1.0 (MD 1.0) is a web based analysis environment that can analyze and visualize LFQ data produced by software such as Maxquant. Unlike other tools, MD 1.0 utilizes cloud-based architecture to enable researchers to store their data, enabling researchers to not only automatically process and visualize their LFQ data but annotate and share their findings with collaborators and, if chosen, to easily publish results to the community. With a view toward increased reproducibility and standardisation in proteomics data analysis and streamlining collaboration between researchers, MD 1.0 requires minimal parameter choices and automatically generates quality control reports to verify experiment integrity. Here, we demonstrate that MD 1.0 provides reliable results for protein expression quantification, emulating Perseus on benchmark datasets over a wide dynamic range. The MD 1.0 platform is available globally via: https://app.massdynamics.com/.

中文翻译：

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Mass Dynamics 1.0：一种基于Web的简化环境，用于分析，共享和集成无标签数据。

shot弹枪蛋白质组学数据的无标签定量分析（LFQ）是一种流行且鲁棒的方法，用于表征样品之间的相对蛋白质丰度。存在许多用于自动化分析的分析管道，并且存在一些工具用于后续表示和检查这些管道的结果。Mass Dynamics 1.0（MD 1.0）是一个基于Web的分析环境，可以分析和可视化由Maxquant之类的软件生成的LFQ数据。与其他工具不同，MD 1.0利用基于云的体系结构来使研究人员能够存储他们的数据，从而使研究人员不仅能够自动处理和可视化他们的LFQ数据，而且还可以与合作者一起注释和共享他们的发现，并且可以轻松地将结果发布到协作者。社区。为了提高蛋白质组学数据分析的可重复性和标准化并简化研究人员之间的协作，MD 1.0要求最少的参数选择并自动生成质量控制报告以验证实验的完整性。在这里，我们证明MD 1.0为蛋白质表达定量提供了可靠的结果，在广泛的动态范围内在基准数据集上模拟了Perseus。MD 1.0平台可通过以下网址在全球范围内使用：https：//app.massdynamics.com/。在广泛的动态范围内，在基准数据集上模拟Perseus。MD 1.0平台可通过以下网址在全球范围内使用：https：//app.massdynamics.com/。在广泛的动态范围内，在基准数据集上模拟Perseus。MD 1.0平台可通过以下网址在全球范围内使用：https：//app.massdynamics.com/。