CO2-Triggered ON/OFF Wettability Switching on Bioinspired Polylactic Acid Porous Films for Controllable Bioadhesion,Biomacromolecules

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CO2-Triggered ON/OFF Wettability Switching on Bioinspired Polylactic Acid Porous Films for Controllable Bioadhesion
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-03-05 , DOI: 10.1021/acs.biomac.1c00134
Hongyao Yin ₁ , Fuxing Zhan ₁ , Zongcheng Li ₁ , Huiyu Huang ₁ , Pierre Marcasuzaa _{2,

3} , Xinjie Luo ₁ , Yujun Feng ₁ , Laurent Billon _{2,

3}

Affiliation

Bioinspired honeycomb-like porous films with switchable properties have drawn much attention recently owing to their potential application in scenarios in which the conversion between two opposite properties is required. Herein, the CO₂-gas-triggered ON/OFF switching wettability of biocompatible polylactic acid (PLA) honeycomb porous films is fabricated. Highly ordered porous films with diameters between 2.0 and 2.8 μm are separately prepared from complexes of nonresponsive PLA and a CO₂-sensitive melamine derivative [N²,N⁴,N⁶-tris(3-(dimethylamino)propyl)-1,3,5-triazine-2,4,6-triamine, MET] via the breath figure method. The hydrophilic CO₂-sensitive groups can be precisely arranged in the pore’s inner surface and/or top surface of the films by simply changing the PLA/MET ratio. The sensitive groups in the pore’s inner surface act as a switch triggered by CO₂ gas controlling water to enter the pores or not, thus resulting in ON/OFF switching wettability. The largest response of the water contact angle of honeycomb films reaches 35°, from 100 to 65°, leading to an obvious hydrophobic–hydrophilic conversion. The improved surface wettability enhances the interaction between the cell and honeycomb film surface, thus resulting in a better cell attachment. Such smart properties accompanying the biocompatible polymer and biological gas trigger facilitate possible biomedical and bioengineering applications in the future for these films.

中文翻译：

生物启发的聚乳酸多孔膜上CO ₂触发的ON / OFF润湿性切换，可控的生物粘附性

具有生物性质的蜂窝状多孔膜具有可切换的特性，由于其潜在的应用前景，在需要两种相反性质之间的转换的情况下，近来引起了人们的极大关注。在此，制造了生物相容性聚乳酸（PLA）蜂窝状多孔膜的CO ₂气体触发的ON / OFF切换润湿性。高度有序的2.0和2.8之间的直径微米分别从非响应PLA的配合物和CO制备的多孔膜₂敏感的三聚氰胺衍生物[ Ñ ²，Ñ ⁴，Ñ ⁶ -三（3-（二甲氨基）丙基）-1,3- ，5-三嗪-2,4,6-三胺，MET]通过呼吸图法。通过简单地改变PLA / MET比，可以将亲水性CO ₂敏感基团精确地布置在膜的孔的内表面和/或顶表面中。孔内表面的敏感基团起CO ₂触发的开关作用气体控制水是否进入毛孔，从而导致ON / OFF开关的润湿性。蜂窝膜与水接触角的最大响应达到35°（从100到65°），从而导致明显的疏水-亲水转化。改进的表面润湿性增强了孔与蜂窝膜表面之间的相互作用，因此导致了更好的孔附着。伴随生物相容性聚合物和生物气体触发物的这种智能特性促进了这些膜在未来可能的生物医学和生物工程应用。

更新日期：2021-04-12

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