Triplet Fusion Upconversion with Oxygen Resistance in Aqueous Media,Analytical Chemistry

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Triplet Fusion Upconversion with Oxygen Resistance in Aqueous Media
Analytical Chemistry ( IF 6.7 ) Pub Date : 2021-03-05 , DOI: 10.1021/acs.analchem.1c00096
Lei Ding ₁ , Jiajia Zhou ₁ , Qiang Fu ₂ , Guochen Bao ₁ , Yongtao Liu ₁ , Dayong Jin _{1,

3}

Affiliation

Triplet fusion upconversion (also called triplet–triplet annihilation, TTA) arouses much attention due to its potential in the fields of biological imaging, optogenetics, and light harvesting. However, oxygen quenching remains a challenge ahead, restricting its applications in aqueous media. Previous efforts to realize aqueous TTA with oxygen resistance have been focused on core–shell structures and self-assembly, but tedious processes and complicated chemical modification are required. Here, we report a direct and efficient strategy to realize aqueous TTA by controlling the ionic equilibrium of the TTA dyad. We find that the ionized organic dyad in physiological buffers and electrolyte-based media shows a natural aerotolerance without any complicated structure engineering. In particular, the upconversion intensity of this aqueous TTA in Tris buffer under an air-saturated condition is more than twice that under the deaerated condition. We further demonstrate the TTA system for potential applications in pH and temperature sensing with reversible and sensitive performance. We anticipate this facile approach will inspire the development of practical aqueous TTA and broad applications in biological science.

中文翻译：

在水介质中具有抗氧性的三重态融合上转换

三重态融合上转换（也称为三重态-三重态an灭，TTA）因其在生物成像，光遗传学和光收集领域的潜力而备受关注。但是，氧气淬火仍然是一个挑战，限制了其在水性介质中的应用。以前为实现具有耐氧性的水性TTA所做的努力已集中在核-壳结构和自组装上，但是需要乏味的过程和复杂的化学修饰。在这里，我们报告了通过控制TTA二元组的离子平衡来实现水性TTA的直接有效策略。我们发现，生理缓冲液和基于电解质的介质中的离子化有机二元化合物显示出自然的耐空气性，而无需进行任何复杂的结构工程。尤其是，在空气饱和条件下，Tris缓冲液中TTA水溶液的上转换强度是在脱气条件下的两倍以上。我们进一步演示了TTA系统在pH和温度传感方面的潜在应用，具有可逆和灵敏的性能。我们预计这种简便的方法将启发实用的TTA水溶液的开发以及在生物科学中的广泛应用。

更新日期：2021-03-16

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