Progress in Tuning Emission of the Excited-State Intramolecular Proton Transfer (ESIPT)-Based Fluorescent Probes,ACS Omega

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Progress in Tuning Emission of the Excited-State Intramolecular Proton Transfer (ESIPT)-Based Fluorescent Probes
ACS Omega ( IF 3.7 ) Pub Date : 2021-03-04 , DOI: 10.1021/acsomega.0c06252
Yonghao Li ₁ , Dipendra Dahal ₁ , Chathura S Abeywickrama ₁ , Yi Pang _{1,

2}

Affiliation

In this review, we will summarize our recent progress in the design and application of novel organic sensors with emission in the near-infrared region (600–900 nm). By coupling different functional groups with excited-state intramolecular proton transfer (ESIPT) segments, new probes are developed to achieve a large Stokes shift, high sensitivity, and selectivity and to tune the emission toward the near-infrared region. The developed probes exhibit attractive optical properties for bioimaging and environmental science applications. In addition, we further discuss the photophysical properties of ESIPT dyes and how their fluorescence could be affected by structural/environmental factors, which should be considered during the development of robust ESIPT-based fluorescence probes. Their potential applications as imaging reagents are illustrated for intracellular membranes, mitochondria, lysosomes, and some biomolecules.

中文翻译：

激发态分子内质子转移（ESIPT）荧光探针发射调控研究进展

在这篇综述中，我们将总结我们在近红外区域（600-900 nm）发射的新型有机传感器的设计和应用方面的最新进展。通过将不同的官能团与激发态分子内质子转移（ESIPT）片段偶联，开发出新的探针，以实现大斯托克斯位移、高灵敏度和选择性，并将发射调整到近红外区域。开发的探针对于生物成像和环境科学应用表现出有吸引力的光学特性。此外，我们还进一步讨论了 ESIPT 染料的光物理特性以及结构/环境因素如何影响其荧光，这些在开发基于 ESIPT 的稳健荧光探针时应予以考虑。它们作为成像试剂的潜在应用包括细胞内膜、线粒体、溶酶体和一些生物分子。

更新日期：2021-03-16

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