Microbubbles versus Extracellular Vesicles as Therapeutic Cargo for Targeting Drug Delivery,ACS Nano

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Microbubbles versus Extracellular Vesicles as Therapeutic Cargo for Targeting Drug Delivery
ACS Nano ( IF 15.8 ) Pub Date : 2021-03-05 , DOI: 10.1021/acsnano.0c10689
Mujib Ullah _{1,

2} , Sai Priyanka Kodam ₂ , Qian Mu ₂ , Asma Akbar ₁

Affiliation

Extracellular vesicles (EVs) and microbubbles are nanoparticles in drug-delivery systems that are both considered important for clinical translation. Current research has found that both microbubbles and EVs have the potential to be utilized as drug-delivery agents for therapeutic targets in various diseases. In combination with EVs, microbubbles are capable of delivering chemotherapeutic drugs to tumor sites and neighboring sites of damaged tissues. However, there are no standards to evaluate or to compare the benefits of EVs (natural carrier) versus microbubbles (synthetic carrier) as drug carriers. Both drug carriers are being investigated for release patterns and for pharmacokinetics; however, few researchers have focused on their targeted delivery or efficacy. In this Perspective, we compare EVs and microbubbles for a better understanding of their utility in terms of delivering drugs to their site of action and future clinical translation.

中文翻译：

微泡与细胞外囊泡作为靶向药物递送的治疗药物

细胞外囊泡（EVs）和微泡是药物递送系统中的纳米颗粒，都被认为对临床翻译很重要。当前的研究发现，微泡和电动汽车都有潜力用作各种疾病中治疗靶标的药物传递剂。结合电动汽车，微泡能够将化学治疗药物递送至肿瘤部位和受损组织的邻近部位。但是，目前尚无评估或比较电动汽车（自然承运人）与微泡（合成载体）作为药物载体。目前正在研究两种药物载体的释放方式和药代动力学。然而，很少有研究者专注于其靶向递送或功效。在此观点中，我们比较了电动汽车和微泡，以便更好地了解它们在将药物输送到其作用部位和未来临床翻译方面的效用。

更新日期：2021-03-23

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